Introduction More than 20 yr ago, in an elegant series of pulsechase studies, Steiner and
Oyer (1) demonstrated that insulin is synthesized in pancreatic islet cells as part of a larger …

The proteases involved in the maturation of regulatory peptides like those of broader
specificity normally fail to cleave peptide bonds linked to the cyclic amino acid proline. This …

This remarkable book is addressed first of all to those chemists, biochemists, physiologists,
and pharmacologists who are interested in melanotropins. However, as it is appropriately …

Using a 796-basepair cDNA fragment obtained from a mouse pituitary library we have
screened two mouse insulinoma libraries and isolated a full-length cDNA clone (2516 …

Multistep proteolytic mechanisms are essential for converting proprotein precursors into
active peptide neurotransmitters and hormones. Cysteine proteases have been implicated in …

Uromodulin (or Tamm-Horsfall protein) is a glycoprotein uniquely produced in the kidney by
tubular cells of the thick ascending limb of the loop of Henle and early distal tubules. This …

There are currently a large number of “orphan” G-protein-coupled receptors (GPCRs) whose
endogenous ligands (peptide hormones) are unknown. Identification of these peptide …

Neuronal development and differentiation require a variety of cell interactions. Diffusible
molecules from target neurons play an important part in mediating such interactions. Our …

Abstract C‐terminal lysine (C‐K) variants are commonly observed in therapeutic monoclonal
antibodies and recombinant proteins. Heterogeneity of C‐K residues is believed to result …

We have identified an amino acid sequence within the E peptide of the insulin-like growth
factor IB (IGF-IB) precursor that is biologically active and designated this peptide insulin-like …