The continued threat of emerging flaviviruses

TC Pierson, MS Diamond - Nature microbiology, 2020 - nature.com
Flaviviruses are vector-borne RNA viruses that can emerge unexpectedly in human
populations and cause a spectrum of potentially severe diseases including hepatitis …

Broad spectrum antiviral agent niclosamide and its therapeutic potential

J Xu, PY Shi, H Li, J Zhou - ACS infectious diseases, 2020 - ACS Publications
The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for
therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an …

Drug repurposing for viral infectious diseases: how far are we?

B Mercorelli, G Palù, A Loregian - Trends in microbiology, 2018 - cell.com
Despite the recent advances in controlling some viral pathogens, most viral infections still
lack specific treatment. Indeed, the need for effective therapeutic strategies to combat 'old' …

Trends and targets in antiviral phototherapy

A Wiehe, JM O'Brien, MO Senge - Photochemical & Photobiological …, 2019 - pubs.rsc.org
Photodynamic therapy (PDT) is a well-established treatment option in the treatment of
certain cancerous and pre-cancerous lesions. Though best-known for its application in …

Niclosamide for Covid-19: bridging the gap

HM Al-Kuraishy, AI Al-Gareeb, KJ Alzahrani… - Molecular Biology …, 2021 - Springer
Aim/purpose Niclosamide (NCL) is an anthelminthic drug, which is widely used to treat
various diseases due to its pleiotropic anti-inflammatory and antiviral activities. NCL …

Allosteric inhibitors of the main protease of SARS-CoV-2

SK Samrat, J Xu, X Xie, E Gianti, H Chen, J Zou… - Antiviral research, 2022 - Elsevier
SARS-CoV-2 has raised the alarm to search for effective therapy for this virus. To date
several vaccines have been approved but few available drugs reported recently still need …

Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids

YP Xu, Y Qiu, B Zhang, G Chen, Q Chen, M Wang… - Cell research, 2019 - nature.com
The re-emergence of Zika virus (ZIKV) in the Western Hemisphere has resulted in global
public health crisis since 2015. ZIKV preferentially infects and targets human neural …

A review on SARS-CoV-2 virology, pathophysiology, animal models, and anti-viral interventions

SN Neerukonda, U Katneni - Pathogens, 2020 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
CoV disease 2019 (COVID-19) is a highly pathogenic and transmissible CoV that is …

Discovery, X-ray crystallography and antiviral activity of allosteric inhibitors of flavivirus NS2B-NS3 protease

Y Yao, T Huo, YL Lin, S Nie, F Wu, Y Hua… - Journal of the …, 2019 - ACS Publications
Flaviviruses, including dengue, West Nile and recently emerged Zika virus, are important
human pathogens, but there are no drugs to prevent or treat these viral infections. The highly …

Niclosamide—A promising treatment for COVID‐19

S Singh, A Weiss, J Goodman, M Fisk… - British journal of …, 2022 - Wiley Online Library
Vaccines have reduced the transmission and severity of COVID‐19, but there remains a
paucity of efficacious treatment for drug‐resistant strains and more susceptible individuals …