Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of
gene control in humans. It provides cells with the opportunity to create protein isoforms of …

K-ras mutations occur frequently in epithelial cancers. Using short hairpin RNAs to deplete K-
Ras in lung and pancreatic cancer cell lines harboring K-ras mutations, two classes were …

Epithelial-mesenchymal transition (EMT) is a highly conserved morphogenic process
defined by the loss of epithelial characteristics and the acquisition of a mesenchymal …

Since the discovery of MSP (macrophage-stimulating protein; also known as MST1 and
hepatocyte growth factor-like (HGFL)) as the ligand for the receptor tyrosine kinase RON …

Background. c‐MET is a receptor tyrosine kinase receptor (RTK) for the hepatocyte growth
factor (HGF). The binding of HGF to c‐MET regulates several cellular functions …

In tumours, aberrant splicing generates variants that contribute to multiple aspects of tumour
establishment, progression and maintenance. We show that in glioblastoma multiforme …

Alternative splicing is a key molecular mechanism for increasing the functional diversity of
the eukaryotic proteomes. A large body of experimental data implicates aberrant splicing in …

Alternative splicing provides a critical and flexible layer of regulation intervening in many
biological processes to regulate the diversity of proteins and impact cell phenotype. To …

In recent years, the notion of “one gene makes one protein that functions in one signaling
pathway” in mammalian cells has been shown to be overly simplistic. Recent genome-wide …