Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …

Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Cancer is one of the main causes of death worldwide. Despite the significant development of
methods of cancer healing during the past decades, chemotherapy still remains the main …

Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as
aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis …

Glycolysis has long been considered as the major metabolic process for energy production
and anabolic growth in cancer cells. Although such a view has been instrumental for the …

Patients with high-grade serous ovarian cancer (HGSC) frequently receive platinum-based
chemotherapeutics, such as cisplatin. Cisplatin binds to DNA and induces DNA-damage …

Breast cancer (BC) is the most prevalent cancer in women. BC is heterogeneous, with
distinct phenotypical and morphological characteristics. These are based on their gene …

Resistance to therapeutic agents, either intrinsic or acquired, is currently a major problem in
the treatment of cancers and occurs in virtually every type of anti-cancer therapy. Therefore …

Targeting altered tumour metabolism is an emerging therapeutic strategy for cancer
treatment. The metabolic reprogramming that accompanies the development of malignancy …

Despite an increasing arsenal of anticancer therapies, many patients continue to have poor
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …