RNA-dependent RNA polymerase as a target for COVID-19 drug discovery
W Zhu, CZ Chen, K Gorshkov, M Xu… - … the Science of Drug …, 2020 - journals.sagepub.com
COVID-19 respiratory disease caused by the severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2) has rapidly become a global health issue since it emerged in December …
2 (SARS-CoV-2) has rapidly become a global health issue since it emerged in December …
Norovirus antivirals: Where are we now?
NE Netzler, D Enosi Tuipulotu… - Medicinal research …, 2019 - Wiley Online Library
Human noroviruses inflict a significant health burden on society and are responsible for
approximately 699 million infections and over 200 000 estimated deaths worldwide each …
approximately 699 million infections and over 200 000 estimated deaths worldwide each …
Inhibitors of the hepatitis C virus polymerase; mode of action and resistance
The hepatitis C virus (HCV) is a pandemic human pathogen posing a substantial health and
economic burden in both developing and developed countries. Controlling the spread of …
economic burden in both developing and developed countries. Controlling the spread of …
New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis
Background The two control points of cholesterol synthesis, 3-hydroxy-3-methylglutaryl-
coenzyme A reductase (HMGCR) and squalene monooxygenase (SQLE) are known targets …
coenzyme A reductase (HMGCR) and squalene monooxygenase (SQLE) are known targets …
Structure (s), function (s), and inhibition of the RNA-dependent RNA polymerase of noroviruses
Noroviruses belong to the Caliciviridae family of single-stranded positive-sense RNA
viruses. The genus Norovirus includes seven genogroups (designated GI-GVII), of which GI …
viruses. The genus Norovirus includes seven genogroups (designated GI-GVII), of which GI …
Development of a fluorescence-based method for the rapid determination of Zika virus polymerase activity and the screening of antiviral drugs
Y Sáez-Álvarez, A Arias, C Del Águila, R Agudo - Scientific reports, 2019 - nature.com
Zika virus (ZIKV) is an emerging pathogen that has been associated with large numbers of
cases of severe neurologic disease, including Guillain-Barré syndrome and microcephaly …
cases of severe neurologic disease, including Guillain-Barré syndrome and microcephaly …
Calicivirus RNA-dependent RNA polymerases: evolution, structure, protein dynamics, and function
The Caliciviridae are viruses with a positive-sense, single-stranded RNA genome that is
packaged into an icosahedral, environmentally stable protein capsid. The family contains …
packaged into an icosahedral, environmentally stable protein capsid. The family contains …
Nucleocytoplasmic shuttling of the West Nile virus RNA‐dependent RNA polymerase NS5 is critical to infection
West Nile virus (WNV) is a single‐stranded, positive sense RNA virus of the family
Flaviviridae and is a significant pathogen of global medical importance. Flavivirus replication …
Flaviviridae and is a significant pathogen of global medical importance. Flavivirus replication …
Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds
R Croci, M Pezzullo, D Tarantino, M Milani, SC Tsay… - PloS one, 2014 - journals.plos.org
Noroviruses (NV) are+ ssRNA viruses responsible for severe gastroenteritis; no effective
vaccines/antivirals are currently available. We previously identified Suramin (9) as a potent …
vaccines/antivirals are currently available. We previously identified Suramin (9) as a potent …
[HTML][HTML] Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex
Coronaviruses contain one of the largest genomes among the RNA viruses, coding for 14–
16 non-structural proteins (nsp) that are involved in proteolytic processing, genome …
16 non-structural proteins (nsp) that are involved in proteolytic processing, genome …