During the past decade enormous advances have been made in our understanding of the
basic molecular machinery that is involved in the development of neuronal polarity. Far from …

The polarity of neurons, which is integral to their function, is a result of the segregated
distribution of molecules and organelles. The polarized distribution of cytoskeletal proteins …

The neuronal microtubule-associated protein tau is required for the development of cell
polarity in cultured neurons. Using PC12 cells that stably express tau and tau amino …

The small GTPases of the Rac/Rho/Cdc42 subfamily are implicated in actin cytoskeleton-
membrane interaction in mammalian cells and budding yeast. The in vivo functions of these …

Conflicting evidence supports a role for tau as an essential neuronal cytoskeletal protein or
as a redundant protein whose function can be fulfilled by other microtubule-associated …

Neurons, the basic information processing units of the nervous system, are characterized by
a complex polar morphology which is essential for their function. To attain their precise …

Axons in the CNS do not regrow after injury, whereas lesioned axons in the peripheral
nervous system (PNS) regenerate. Lesioned CNS axons form characteristic swellings at …

Tau is a developmentally regulated microtubule-associated protein that influences
microtubule behavior by directly associating with tubulin. The carboxyl terminus of tau …

Here we report the description of the Drosophila gene futsch, which encodes a protein
recognized by the monoclonal antibody 22C10 that has been widely used to visualize …

Microtubule-associated protein 2 (MAP2) is a major component of cross-bridges between
microtubules in dendrites, and is known to stabilize microtubules. MAP2 also has a binding …