Collagen is a ubiquitous biomaterial in vertebrate animals. Although each of its 28 subtypes
contributes to the functions of many different tissues in the body, most studies on collagen or …

Osteoarthritis is a painful joint disease characterized by progressive degeneration of the
articular cartilage as well as associated changes to the subchondral bone, synovium, and …

Hip and knee osteoarthritis (OA) are leading causes of global disability. Most research to
date has focused on the knee, with results often extrapolated to the hip, and this extends to …

Collagen VI represents a remarkable extracellular matrix molecule, and in the past few
years, studies of this molecule have revealed its involvement in a wide range of tissues and …

Mechanical stress plays a critical role in cartilage development and homoeostasis.
Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs …

The extracellular matrix (ECM) is synthesized and secreted by embryonic cells beginning at
the earliest stages of development. Our understanding of ECM composition, structure and …

Chondrocytes in articular cartilage are surrounded by a narrow pericellular matrix (PCM)
that is both biochemically and biomechanically distinct from the extracellular matrix (ECM) of …

Articular cartilage is a connective tissue consisting of a specialized extracellular matrix
(ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are …

Adult muscle stem cells, or satellite cells have essential roles in homeostasis and
regeneration of skeletal muscles. Satellite cells are located within a niche that includes …

Articular cartilage injuries and degenerative joint diseases are responsible for progressive
pain and disability in millions of people worldwide, yet there is currently no treatment …