Structural gene rearrangements resulting in gene fusions are frequent events in solid
tumours. The identification of certain activating fusions can aid in the diagnosis and effective …

In the US, approximately 650 children are diagnosed with osteosarcoma and Ewing
sarcoma (ES) each year. Five‐year survival ranges from 65% to 75% for localized disease …

Purpose: Ewing sarcoma is a pediatric bone tumor that absolutely relies on the
transcriptional activity of the EWS/ETS family of fusion oncoproteins. While the most common …

Covering: up to 2014 The ecteinascidin family comprises a number of biologically active
compounds, containing two to three tetrahydroisoquinoline subunits. Although isolated from …

Tumor development is a complex process resulting from interplay between mutations in
oncogenes and tumor suppressors, host susceptibility factors, and cellular context. Great …

Ewing sarcoma is a high-grade round cell sarcoma that affects bones and soft tissues in
children and young adults. Its diagnosis can be challenging, and the differential diagnoses …

Ewing sarcoma provides an important model for transcription-factor-mediated oncogenic
transformation because of its reliance on the ETS-type fusion oncoprotein EWS/FLI. EWS/FLI …

Approximately one-third of sarcomas contain specific translocations. Ewing sarcoma is the
prototypical member of this group of sarcomas; it was the first to be recognized …

Patients with metastatic or recurrent and refractory sarcomas have a dismal prognosis.
Therefore, new targeted therapies are urgently needed. This study was designed to evaluate …

FUS, EWS, and TAF15 form the FET family of RNA‐binding proteins whose genes are found
rearranged with various transcription factor genes predominantly in sarcomas and in rare …