Neurodegenerative disorders have been considered as a growing health concern for
decades. Increasing risk of neurodegenerative disorders creates a socioeconomic burden to …

Glioma stem-like cells (GSCs) were first described as a population which may in part be
resistant to traditional chemotherapeutic therapies and responsible for tumour regrowth …

Glioblastoma multiforme (GBM) is an aggressive adult brain tumour with poor prognosis.
Roles for peptidylarginine deiminases (PADs) in GBM have recently been highlighted. Here …

Glioblastoma (GBM) represents a significant therapeutic challenge due to its aggressive
nature. Tumor Treating Fields (TTFields) present a promising approach to GBM therapy. The …

Despite the anti-proliferative and survival benefits from tumor treating fields (TTFields) in
human glioblastoma (hGBM), little is known about the effects of this form of alternating …

Pyruvate kinase (PK) catalyzes the last irreversible reaction of glycolysis pathway,
generating pyruvate and ATP, from Phosphoenol Pyruvate (PEP) and ADP precursors. In …

The development of gene delivery vehicles with high organ specificity when administered
systemically is a critical goal for gene therapy. We combine optical and positron emission …

Abstract Purpose: Pyruvate kinase M2 (PKM2) catalyzes the final step in glycolysis, a key
process of cancer metabolism. PKM2 is preferentially expressed by glioblastoma (GBM) …

The development of new, effective drugs containing nitrogen and sulfur heteroatoms is of
paramount importance in medicinal chemistry. A versatile and rational approach for drug …

Purpose: To analyze and review the progress of glucose metabolism-based molecular
imaging in detecting tumors to guide clinicians for new management strategies. Summary …