Forkhead box proteins: tuning forks for transcriptional harmony
EWF Lam, JJ Brosens, AR Gomes, CY Koo - Nature Reviews Cancer, 2013 - nature.com
Forkhead box (FOX) proteins are multifaceted transcription factors that are responsible for
fine-tuning the spatial and temporal expression of a broad range of genes both during …
fine-tuning the spatial and temporal expression of a broad range of genes both during …
Building and regenerating the lung cell by cell
JA Whitsett, TV Kalin, Y Xu… - Physiological …, 2019 - journals.physiology.org
The unique architecture of the mammalian lung is required for adaptation to air breathing at
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …
FOXM1: A key oncofoetal transcription factor in health and disease
L Bella, S Zona, GN de Moraes, EWF Lam - Seminars in cancer biology, 2014 - Elsevier
Abstract Forkhead Box M1 (FOXM1) is a bona fide oncofoetal transcription factor, which
orchestrates complex temporal and spatial gene expression throughout embryonic and …
orchestrates complex temporal and spatial gene expression throughout embryonic and …
Nanoparticle delivery systems with cell-specific targeting for pulmonary diseases
Respiratory disorders are among the most important medical problems threatening human
life. The conventional therapeutics for respiratory disorders are hindered by insufficient drug …
life. The conventional therapeutics for respiratory disorders are hindered by insufficient drug …
FOXF1 transcription factor is required for formation of embryonic vasculature by regulating VEGF signaling in endothelial cells
X Ren, V Ustiyan, A Pradhan, Y Cai… - Circulation …, 2014 - Am Heart Assoc
Rationale: Inactivating mutations in the Forkhead Box transcription factor F1 (FOXF1) gene
locus are frequently found in patients with alveolar capillary dysplasia with misalignment of …
locus are frequently found in patients with alveolar capillary dysplasia with misalignment of …
In Vivo Generation of Lung and Thyroid Tissues from Embryonic Stem Cells Using Blastocyst Complementation
Rationale: The regeneration and replacement of lung cells or tissues from induced
pluripotent stem cell–or embryonic stem cell–derived cells represent future therapies for life …
pluripotent stem cell–or embryonic stem cell–derived cells represent future therapies for life …
Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells
Rationale: Disruption of alveologenesis is associated with severe pediatric lung disorders,
including bronchopulmonary dysplasia (BPD). Although c-KIT+ endothelial cell (EC) …
including bronchopulmonary dysplasia (BPD). Although c-KIT+ endothelial cell (EC) …
The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice
Goblet cell metaplasia and excessive mucus secretion associated with asthma, cystic
fibrosis, and chronic obstructive pulmonary disease contribute to morbidity and mortality …
fibrosis, and chronic obstructive pulmonary disease contribute to morbidity and mortality …
Generation of pulmonary endothelial progenitor cells for cell-based therapy using interspecies mouse–rat chimeras
Rationale: Although pulmonary endothelial progenitor cells (EPCs) hold promise for cell-
based therapies for neonatal pulmonary disorders, whether EPCs can be derived from …
based therapies for neonatal pulmonary disorders, whether EPCs can be derived from …
FOXF1 maintains endothelial barrier function and prevents edema after lung injury
Multiple signaling pathways, structural proteins, and transcription factors are involved in the
regulation of endothelial barrier function. The forkhead protein FOXF1 is a key …
regulation of endothelial barrier function. The forkhead protein FOXF1 is a key …