Fungal endophytes are well-established sources of biologically active natural compounds
with many producing pharmacologically valuable specific plant-derived products. This …

Signal transducer and activator of transcription 3 (STAT3) is one of seven STAT family
members involved with the regulation of cellular growth, differentiation and survival. STAT …

Excessive activation of signal transducer and activator of transcription 3 (STAT3) signaling is
observed in a subset of many cancers, making activated STAT3 a highly promising potential …

Osteosarcoma is the most common primary malignant bone tumor in children and
adolescents, with highly aggressive behavior and early systemic metastasis. The survival …

Colorectal cancer (CRC) is a disease with complex pathogenesis, it is prone to metastasis,
and its development involves abnormalities in multiple signaling pathways. Surgery …

T cell–based immunotherapy holds promise for treating solid tumors, but its therapeutic
efficacy is limited by intratumoral immune suppression. This immune suppressive tumor …

Pancreatic cancer is lethal in over 90% of cases since it is resistant to current therapeutic
strategies. The key role of STAT3 in promoting pancreatic cancer progression has been …

Toosendanin (TSN), extracted from Melia. toosendan Sieb. et Zucc. and Melia. azedarach L.,
has been developed into an ascaris repellent in China. However, with the improvement of …

Background Signal transducer and activator of transcription 3 (STAT3) is an oncogene,
which upregulates in approximately 70% of human cancers. Autophagy is an evolutionarily …

Background Diosmetin is a bioflavonoid compound naturally abundant in citrus fruits. It is
found to perform a variety of activities, while its antitumor property in osteosarcoma, a …