The diversity of dicarboxylic acid anhydrides employable in the Castagnoli–Cushman
reaction (CCR) was traditionally thought to be limited to the classical succinic and glutaric …

Over the last decade, Diversity-Oriented Synthesis (DOS) has become a new paradigm for
developing large collections of structurally diverse small molecules as probes to investigate …

The first nickel (0)-catalyzed [2+ 2+ 1] carbonylative cycloaddition reaction of imines and
alkynes or norbornene has been achieved by employing phenyl formate as a CO source …

Recent studies have discovered that aryl-substituted pyrido [2, 1-a] isoquinolines have the
potential to be highly active DPP IV inhibitors. In previous studies, we reported a novel …

A Pd-catalyzed asymmetric allylic amination of 4-substituted 2-acetoxybut-3-enoates with
amines has been developed for the regiospecific synthesis of chiral α, β-unsaturated γ …

The first asymmetric synthesis of spiro-γ-lactam oxindoles bearing three stereocenters is
reported. One-pot thiol-Michael/Mannich/lactamization reactions promoted by a recyclable …

Since the first reports of the reaction of imines and cyclic anhydrides by Castagnoli and
Cushman, this procedure has been applied to the synthesis of a variety of lactams, some of …

Computations (SCS-MP2//B3LYP) reveal that the asymmetric synthesis of highly substituted
γ-lactams with three stereogenic centers, including one quaternary center, proceeds through …

A reaction between imines and anhydrides has been developed with chiral disubstituted
anhydrides and chiral imines. The synthesis of highly substituted γ-lactams with three …

Sulfone-substituted γ-and δ-lactams have been prepared in a single step with high
diastereoselectivity. Sulfonylglutaric anhydrides produce intermediates that readily …