Telomere length and telomerase activity are important factors in the pathobiology of human
disease. Age-related diseases and premature ageing syndromes are characterized by short …

Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are
progressively lost with each round of cell division. Telomere protection requires a minimal …

At close hand to one's genomic material are the histones that make up the nucleosome.
Standing guard, one variant stays hidden doubling as one of the core histones. But, thanks …

Aging can be defined as progressive functional decline and increasing mortality over time.
Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates …

Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …

Most normal human cells undergo cellular senescence after accruing a fixed number of cell
divisions, or are challenged by a variety of potentially oncogenic stimuli, in culture and most …

Telomeres are capping structures at the ends of eukaryotic chromosomes composed of
TTAGGG repeats bound to an array of specialized proteins,,. Telomeres are heterochromatic …

The efficient repair of DNA double-strand breaks is crucial in safeguarding the genomic
integrity of organisms. Responses to double-strand breaks include complex signal …

Ku is of central importance to DNA repair in eukaryotes. In addition, Ku has a key role in a
number of other fundamental cellular processes such as telomere maintenance …

A major limitation of studies of the relevance of telomere length to cancer and age-related
diseases in human populations and to the development of telomere-based therapies has …