The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …

Runx2 is essential for osteoblast differentiation and chondrocyte maturation. During
osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells …

Bone tissue regeneration is augmented by biocompatible nanofiber scaffolds, that supports
reliable and enhanced bone formation. Zinc is an essential mineral that is vital for routine …

Osteocalcin (Ocn), which is specifically produced by osteoblasts, and is the most abundant
non-collagenous protein in bone, was demonstrated to inhibit bone formation and function …

Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …

RUNX2 is a multifunctional transcription factor that controls skeletal development by
regulating the differentiation of chondrocytes and osteoblasts and the expression of many …

Both activating and null mutations of proteins required for canonical WNT signaling have
revealed the importance of this pathway for normal skeletal development. However, tissue …

The major event that triggers osteogenesis is the transition of mesenchymal stem cells into
bone forming, differentiating osteoblast cells. Osteoblast differentiation is the primary …

Beyond being aging-related diseases, atherosclerosis and osteoporosis share common
pathogenetic pathways implicated in bone and vascular mineralization. However, the …

The effects of pore size in additively manufactured biodegradable porous magnesium on the
mechanical properties and biodegradation of the scaffolds as well as new bone formation …