Metformin is a widely used drug in today's prescriptions by physicians due to its specific
effects in treating and curing type II diabetes. Diabetes is a common disease that may occur …

Abstract Purpose of Review Since epidemiological studies first demonstrated a potential
positive effect of metformin in reducing cancer incidence and mortality, there has been an …

Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa).
The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress …

Prostate cancer (PCa) is a malignant disorder of prostate gland being asymptomatic in early
stages and high metastatic potential in advanced stages. The chemotherapy and surgical …

Exposure to ionizing radiation (IR) increases the production of reactive oxygen species
(ROS) not only by the radiolysis of water but also through IR-induced perturbation of the …

Over the last decade, evidence has emerged to support a role for the antidiabetic drug
metformin in the prevention and treatment of cancer. In particular, recent studies …

Metformin is the most used drug for type 2 diabetes (T2DM). Its antitumor activity has been
described by clinical studies showing reduced risk of cancer development in T2DM patients …

Over the last years, repurposed agents have provided growing evidence of fast
implementation in oncology treatment such as certain antimalarial, anthelmintic, antibiotics …

Metformin is the first-line oral antidiabetic drug that shows multiple pleiotropic effects of anti-
inflamation, anti-cancer, anti-aging, anti-microbia, anti-atherosclerosis, and immune …

Early studies indicated that the testicular nuclear receptor 4 (TR4) might play key roles in
altering prostate cancer (PCa) progression; however, its ability to alter PCa radiosensitivity …