DYRK1A and cognition: A lifelong relationship
ML Arbones, A Thomazeau… - Pharmacology & …, 2019 - Elsevier
The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …
(CNS) during development and aging. This review analyzes the functions of this kinase by …
NACSELD acute‐on‐chronic liver failure (NACSELD‐ACLF) score predicts 30‐day survival in hospitalized patients with cirrhosis
Several highly effective, interferon‐free, direct‐acting antiviral (DAA)‐based regimens are
available for the treatment of chronic hepatitis C virus (HCV) infection. Despite impressive …
available for the treatment of chronic hepatitis C virus (HCV) infection. Despite impressive …
Regulation and function of capicua in mammals
Y Lee - Experimental & molecular medicine, 2020 - nature.com
Capicua (CIC) is an evolutionarily conserved transcription factor. CIC contains a high-
mobility group (HMG) box that recognizes specific DNA sequences to regulate the …
mobility group (HMG) box that recognizes specific DNA sequences to regulate the …
[PDF][PDF] Capicua suppresses hepatocellular carcinoma progression by controlling the ETV4–MMP1 axis
Hepatocellular carcinoma (HCC) is developed by multiple steps accompanying progressive
alterations of gene expression, which leads to increased cell proliferation and malignancy …
alterations of gene expression, which leads to increased cell proliferation and malignancy …
The tumor suppressor CIC directly regulates MAPK pathway genes via histone deacetylation
Oligodendrogliomas are brain tumors accounting for approximately 10% of all central
nervous system cancers. CIC is a transcription factor that is mutated in most patients with …
nervous system cancers. CIC is a transcription factor that is mutated in most patients with …
The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer
The transcriptional repressor Capicua (CIC) has emerged as an important rheostat of cell
growth regulated by RAS/MAPK signaling. Cic was originally discovered in Drosophila …
growth regulated by RAS/MAPK signaling. Cic was originally discovered in Drosophila …
The mitochondrial ribosomal protein mRpL4 regulates Notch signaling
D Mo, C Liu, Y Chen, X Cheng, J Shen, L Zhao… - EMBO …, 2023 - embopress.org
Mitochondrial ribosomal proteins (MRPs) assemble as specialized ribosome to synthesize
mtDNA‐encoded proteins, which are essential for mitochondrial bioenergetic and metabolic …
mtDNA‐encoded proteins, which are essential for mitochondrial bioenergetic and metabolic …
Transcriptomic analysis of CIC and ATXN1L reveal a functional relationship exploited by cancer
D Wong, K Lounsbury, A Lum, J Song, S Chan… - Oncogene, 2019 - nature.com
Aberrations in Capicua (CIC) have recently been implicated as a negative prognostic factor
in a multitude of cancer types through activation of the MAPK signalling cascade and …
in a multitude of cancer types through activation of the MAPK signalling cascade and …
Gypsy moth genome provides insights into flight capability and virus–host interactions
Since its accidental introduction to Massachusetts in the late 1800s, the European gypsy
moth (EGM; Lymantria dispar dispar) has become a major defoliator in North American …
moth (EGM; Lymantria dispar dispar) has become a major defoliator in North American …
Comparative transcriptome analysis of isogenic cell line models and primary cancers links capicua (CIC) loss to activation of the MAPK signalling cascade
VG LeBlanc, M Firme, J Song, SY Chan… - The Journal of …, 2017 - Wiley Online Library
CIC encodes a transcriptional repressor, capicua (CIC), whose disrupted activity appears to
be involved in several cancer types, including type I low‐grade gliomas (LGGs) and stomach …
be involved in several cancer types, including type I low‐grade gliomas (LGGs) and stomach …