The S100B story: from biomarker to active factor in neural injury

F Michetti, N D'Ambrosi, A Toesca… - Journal of …, 2019 - Wiley Online Library
S100B is a Ca2+‐binding protein mainly concentrated in astrocytes. Its levels in biological
fluids (cerebrospinal fluid, peripheral and cord blood, urine, saliva, amniotic fluid) are …

DAMPs and RAGE pathophysiology at the acute phase of brain injury: an overview

B Balança, L Desmurs, J Grelier… - International Journal of …, 2021 - mdpi.com
Early or primary injury due to brain aggression, such as mechanical trauma, hemorrhage or
is-chemia, triggers the release of damage-associated molecular patterns (DAMPs) in the …

Astrocyte culture models: Molecular and function characterization of primary culture, immortalized astrocytes and C6 glioma cells

F Galland, M Seady, J Taday, SS Smaili… - Neurochemistry …, 2019 - Elsevier
The understanding of the physiology of astrocytes and their role in brain function progresses
continuously. Primary astrocyte culture is an alternative method to study these cells in an …

[HTML][HTML] Human induced pluripotent stem cell–derived extracellular vesicles reduce hepatic stellate cell activation and liver fibrosis

D Povero, EM Pinatel, A Leszczynska, NP Goyal… - JCI insight, 2019 - ncbi.nlm.nih.gov
Progression of fibrosis and the development of cirrhosis are responsible for the liver-related
morbidity and mortality associated with chronic liver diseases. There is currently a great …

S100B actions on glial and neuronal cells in the developing brain: An overview

K Hernández-Ortega, AA Canul-Euan… - Frontiers in …, 2024 - frontiersin.org
The S100B is a member of the S100 family of “E” helix–loop-“F” helix structure (EF) hand
calcium-binding proteins expressed in diverse glial, selected neuronal, and various …

Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding

GG Moreira, FX Cantrelle, A Quezada… - Nature …, 2021 - nature.com
The microtubule-associated protein tau is implicated in the formation of oligomers and
fibrillar aggregates that evade proteostasis control and spread from cell-to-cell. Tau …

Tau liquid–liquid phase separation is modulated by the Ca2+‐switched chaperone activity of the S100B protein

GG Moreira, CM Gomes - Journal of Neurochemistry, 2023 - Wiley Online Library
Aggregation of the microtubule‐associated protein tau is implicated in several
neurodegenerative tauopathies including Alzheimer's disease (AD). Recent studies …

How S100B crosses brain barriers and why it is considered a peripheral marker of brain injury

V Gayger-Dias, AFK Vizuete… - Experimental …, 2023 - journals.sagepub.com
S100B is a 21-kDa protein that is produced and secreted by astrocytes and widely used as a
marker of brain injury in clinical and experimental studies. The majority of these studies are …

S100β‐mediated astroglial control of firing and input processing in layer 5 pyramidal neurons of the mouse visual cortex

D Ryczko, M Hanini‐Daoud… - The Journal of …, 2021 - Wiley Online Library
Key points Inputs impinging on layer 5 pyramidal neurons perform essential operations as
these cells represent one of the most important output carriers of the cerebral cortex …

A self-assembled DNA-nanoparticle with a targeting peptide for hypoxia-inducible gene therapy of ischemic stroke

J Oh, J Lee, C Piao, JH Jeong, M Lee - Biomaterials science, 2019 - pubs.rsc.org
A self-assembled nanoparticle composed of hypoxia-specific anti-RAGE peptide (HSAP),
heme oxygenase-1 plasmid (pHO1), and deoxycholate-conjugated polyethylenimine-2k …