Thymosin β4 (Tβ4) is the β-thymosin (Tβs) with the highest expression level in human cells;
it makes up roughly 70-80% of all Tβs in the human body. Combining the mechanism and …

Background Diabetes mellitus causes microcirculatory rarefaction and may impair the
responsiveness of ischemic myocardium to proangiogenic factors. Objectives This study …

Recent studies reveal a crucial role of pericyte loss in sepsis-associated microvascular
dysfunction. Sirtuin 3 (SIRT3) mediates histone protein post-translational modification …

Introduction: Formation of the vasculature is a complex process, defects in which can lead to
embryonic lethality or disease in later life. Understanding mechanisms of vasculogenesis …

Abstract Background Thymosin beta 4×(Tmsb4x) has been highlighted as an important
regulator in immune and inflammation responses. Promoted differentiation of mononuclear …

The high mortality seen in sepsis is caused by a systemic hypotension in part owing to a
drastic increase in vascular permeability accompanied by a loss of pericytes. As has been …

Viral vectors have been frequently used in a variety of preclinical animal models to deliver
genetic constructs into tissues. Among the vectors used, adeno-associated viral vectors …

Introduction: Sepsis is the dysregulated host response to an infection resulting in life-
threatening organ damage. Thymosin Beta 4 is an actin binding protein that inhibits the …

Translations of new therapeutic options for cardiovascular disease from animal studies into
a clinical setting have been hampered, in part by an improper reflection of a relevant patient …

The β-thymosins are a group of structurally related, highly conserved intracellular small
peptides in vertebrates with various biological functions, including cytoskeletal remodeling …