Methylenetetrahydrofolate (MTHFR), the one-carbon cycle, and cardiovascular risks
S Raghubeer, TE Matsha - Nutrients, 2021 - mdpi.com
The 5-10-methylenetetrahydrofolate reductase (MTHFR) enzyme is vital for cellular
homeostasis due to its key functions in the one-carbon cycle, which include methionine and …
homeostasis due to its key functions in the one-carbon cycle, which include methionine and …
Association of homocysteine with type 2 diabetes: a meta-analysis implementing Mendelian randomization approach
Background We tested the hypothesis that elevated homocysteine (Hcy) level is causally
associated with increased risk of type 2 diabetes mellitus (T2DM). Results The meta …
associated with increased risk of type 2 diabetes mellitus (T2DM). Results The meta …
Methylenetetrahydrofolate reductase C677T polymorphism and type 2 diabetes mellitus in Chinese population: a meta-analysis of 29 case-control studies
B Zhu, X Wu, X Zhi, L Liu, Q Zheng, G Sun - PloS one, 2014 - journals.plos.org
Background Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate
metabolism, had significant effects on the homocysteine levels. The common functional …
metabolism, had significant effects on the homocysteine levels. The common functional …
Renin-angiotensin system polymorphisms in relation to hypertension status and obesity in a Tunisian population
S Mehri, S Mahjoub, S Hammami, A Zaroui… - Molecular biology …, 2012 - Springer
Essential hypertension (HTA) is the clinical expression of a disordered interaction between
the genetic, physiological, and biochemical systems that under usual conditions maintain …
the genetic, physiological, and biochemical systems that under usual conditions maintain …
Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility
Y Meng, X Liu, K Ma, L Zhang, M Lu… - … Genetics & Genomic …, 2019 - Wiley Online Library
Introduction Methylenetetrahydrofolate reductase (MTHFR) is essential in mediating folate
metabolism, and thus plays an important role in diabetes and diabetic complications …
metabolism, and thus plays an important role in diabetes and diabetic complications …
ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis
In this meta-analysis study, SNPs were investigated for their association with type 2 diabetes
(T2D) in both Arab and Caucasian ethnicities. A total of 55 SNPs were analyzed, of which 11 …
(T2D) in both Arab and Caucasian ethnicities. A total of 55 SNPs were analyzed, of which 11 …
Meta-analysis of MTHFR C677T polymorphism and type 2 diabetes mellitus in MENA region
Background and aims The association of the C677T polymorphism of the
Methylenetetrahydrofolate Reductase (MTHFR) gene with susceptibility to type 2 diabetes …
Methylenetetrahydrofolate Reductase (MTHFR) gene with susceptibility to type 2 diabetes …
Methylenetetrahydrofolate reductase (MTHFR)(C677T and A1298C) polymorphisms and vascular complications in patients with type 2 diabetes
N Fekih-Mrissa, M Mrad, H Ibrahim, I Akremi… - Canadian journal of …, 2017 - Elsevier
Objectives To assess whether 2 polymorphisms of the methylenetetrahydrofolate reductase
(MTHFR) gene, C677T and A1298C, are risk factors for vascular complications in Tunisian …
(MTHFR) gene, C677T and A1298C, are risk factors for vascular complications in Tunisian …
Methylenetetrahydrofolate reductase gene polymorphism and risk of type 2 diabetes mellitus
JH Zhong, AC Rodríguez, NN Yang, LQ Li - PLoS One, 2013 - journals.plos.org
Objective This review aimed to comprehensively assess the literature examining a possible
link between the rs1801133 polymorphism (677C→ T) in the gene encoding the …
link between the rs1801133 polymorphism (677C→ T) in the gene encoding the …
Genetic risk of type 2 diabetes in populations of the African continent: A systematic review and meta-analyses
Abstract Background Type 2 diabetes (T2D) is growing faster in Africa than anywhere else,
driven by the dual effects of genetic and environmental factors. We conducted a systematic …
driven by the dual effects of genetic and environmental factors. We conducted a systematic …