[HTML][HTML] Are whole-exome and whole-genome sequencing approaches cost-effective? A systematic review of the literature
Purpose We conducted a systematic literature review to summarize the current health
economic evidence for whole-exome sequencing (WES) and whole-genome sequencing …
economic evidence for whole-exome sequencing (WES) and whole-genome sequencing …
Pharmacogenomics in the clinic
MV Relling, WE Evans - Nature, 2015 - nature.com
After decades of discovery, inherited variations have been identified in approximately 20
genes that affect about 80 medications and are actionable in the clinic. And some …
genes that affect about 80 medications and are actionable in the clinic. And some …
[HTML][HTML] The complete costs of genome sequencing: a microcosting study in cancer and rare diseases from a single center in the United Kingdom
Purpose The translation of genome sequencing into routine health care has been slow,
partly because of concerns about affordability. The aspirational cost of sequencing a …
partly because of concerns about affordability. The aspirational cost of sequencing a …
Is the $1000 genome as near as we think? A cost analysis of next-generation sequencing
KJM van Nimwegen, RA van Soest… - Clinical …, 2016 - academic.oup.com
BACKGROUND The substantial technological advancements in next-generation
sequencing (NGS), combined with dropping costs, have allowed for a swift diffusion of NGS …
sequencing (NGS), combined with dropping costs, have allowed for a swift diffusion of NGS …
The future of precision medicine: potential impacts for health technology assessment
J Love-Koh, A Peel, JC Rejon-Parrilla, K Ennis… - …, 2018 - Springer
Objective Precision medicine allows healthcare interventions to be tailored to groups of
patients based on their disease susceptibility, diagnostic or prognostic information, or …
patients based on their disease susceptibility, diagnostic or prognostic information, or …
[HTML][HTML] Clinical application of genome and exome sequencing as a diagnostic tool for pediatric patients: a scoping review of the literature
Purpose Availability of clinical genomic sequencing (CGS) has generated questions about
the value of genome and exome sequencing as a diagnostic tool. Analysis of reported CGS …
the value of genome and exome sequencing as a diagnostic tool. Analysis of reported CGS …
Cost-effectiveness analyses of genetic and genomic diagnostic tests
Developments in next-generation sequencing technologies have driven the clinical
application of diagnostic tests that interrogate the whole genome, which offer the chance to …
application of diagnostic tests that interrogate the whole genome, which offer the chance to …
Clinical utility of genomic sequencing: a measurement toolkit
Whole-genome sequencing (WGS) is positioned to become one of the most robust
strategies for achieving timely diagnosis of rare genomic diseases. Despite its favorable …
strategies for achieving timely diagnosis of rare genomic diseases. Despite its favorable …
The economic case for precision medicine
SP Gavan, AJ Thompson, K Payne - Expert review of precision …, 2018 - Taylor & Francis
Introduction: The advancement of precision medicine into routine clinical practice has been
highlighted as an agenda for national and international health care policy. A principle barrier …
highlighted as an agenda for national and international health care policy. A principle barrier …
Economic evaluations of predictive genetic testing: A scoping review
Predictive genetic testing can provide information about whether or not someone will
develop or is likely to develop a specific condition at a later stage in life. Economic …
develop or is likely to develop a specific condition at a later stage in life. Economic …