Cancer has been characterized as a genetic disease, associated with mutations that cause
pathological alterations of the cell cycle, adhesion, or invasive motility. Recently, the …

This review describes the role of bone cells and their surrounding matrix in maintaining
bone strength through the process of bone remodeling. Subsequently, this work focusses on …

Bone is an active organ that continuously undergoes an orchestrated process of remodeling
throughout life. Bone tissue is uniquely capable of adapting to loading, hormonal, and other …

Microfluidic-based tissue-on-a-chip devices have generated significant research interest for
biomedical applications, such as pharmaceutical development, as they can be used for …

Osteoarthritis (OA) is a multifaceted musculoskeletal disorder, with a high prevalence
worldwide. Articular cartilage and synovial membrane are among the main biological targets …

Bone tissue engineering (BTE) experiments in vitro have shown that fluid-induced wall
shear stress (WSS) can stimulate cells to produce mineralized extracellular matrix (ECM) …

With the development of modern medicine, the research methods of occurrence,
development and treatment of orthopedic diseases are developing rapidly. The …

The conceptual model of the mechanostat proposed by Harold Frost in 1983 is among the
most significant contributions to musculoskeletal research today. This model states that bone …

Wnt signaling plays a critical role in loading-driven bone formation and bone homeostasis,
whereas its activation in cancer cells promotes their progression. Currently, major research …

Primary bone tumors such as Ewing sarcoma, osteosarcoma, and chondrosarcoma,
secondary bone tumors developed from progressive malignancies, and metastasized bone …