Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis

S Mateen, A Zafar, S Moin, AQ Khan, S Zubair - Clinica chimica acta, 2016 - Elsevier
Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease of unknown
etiology. It is characterized by the presence of rheumatoid factor and anti-citrullinated …

Interleukin-6 in rheumatoid arthritis

F Pandolfi, L Franza, V Carusi, S Altamura… - International journal of …, 2020 - mdpi.com
The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent
years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in …

Volatile organic compounds: a proinflammatory activator in autoimmune diseases

JO Ogbodo, AV Arazu, TC Iguh, NJ Onwodi… - Frontiers in …, 2022 - frontiersin.org
The etiopathogenesis of inflammatory and autoimmune diseases, including pulmonary
disease, atherosclerosis, and rheumatoid arthritis, has been linked to human exposure to …

The role of cytokines in the pathogenesis of rheumatoid arthritis–Practical and potential application of cytokines as biomarkers and targets of personalized therapy

E Brzustewicz, E Bryl - Cytokine, 2015 - Elsevier
Rheumatoid arthritis (RA), as a common chronic disease leading to severe disability,
requires early diagnosis and introduction of proper treatment. Deregulation in the cytokine …

Interleukin-1-interleukin-17 signaling axis induces cartilage destruction and promotes experimental osteoarthritis

HS Na, JS Park, KH Cho, JY Kwon, JW Choi… - Frontiers in …, 2020 - frontiersin.org
Osteoarthritis (OA), which is the most common degenerative joint disorder, has been
considered a non-inflammatory disease with abnormal mechanics. Interleukin (IL)-17 is a …

IL-38: a new player in inflammatory autoimmune disorders

L Xie, Z Huang, H Li, X Liu, SG Zheng, W Su - Biomolecules, 2019 - mdpi.com
Interleukin (IL)-38, a newly discovered IL-1 family cytokine, is expressed in several tissues
and secreted by various cells. IL-38 has recently been reported to exert an anti-inflammatory …

Genetic polymorphisms associated with rheumatoid arthritis development and antirheumatic therapy response

DS Mikhaylenko, MV Nemtsova, IV Bure… - International journal of …, 2020 - mdpi.com
Rheumatoid arthritis (RA) is the most common inflammatory arthropathy worldwide. Possible
manifestations of RA can be represented by a wide variability of symptoms, clinical forms …

Molecular genetic investigation, clinical features, and response to treatment in 21 patients with Schnitzler syndrome

DM Rowczenio, S Pathak, JI Arostegui… - Blood, The Journal …, 2018 - ashpublications.org
To date, the pathogenic mechanisms underlying Schnitzler syndrome remain obscure, in
particular, the interplay between the monoclonal protein and increased interleukin-1β (IL-1β) …

Evaluation of antiarthritic and antinociceptive effects of cedrol in a rat model of arthritis

F Forouzanfar, AM Pourbagher-Shahri… - … Medicine and Cellular …, 2022 - Wiley Online Library
Pharmacological studies revealed that cedrol, a natural sesquiterpene, has antioxidant, anti‐
inflammatory, and analgesic properties. This study is aimed at evaluating the potential …

Critical assessment of pharmacokinetic drug–drug interaction potential of tofacitinib, baricitinib and upadacitinib, the three approved janus kinase inhibitors for …

V Veeravalli, RP Dash, JA Thomas, RJ Babu… - Drug safety, 2020 - Springer
The introduction of novel, small-molecule Janus kinase inhibitors namely tofacitinib,
baricitinib and upadacitinib has provided an alternative treatment option for patients with …