Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Myelination of axons in the nervous system of vertebrates enables fast, saltatory impulse
propagation, one of the best-understood concepts in neurophysiology. However, it took a …

X chromosome inactivation (XCI) silences most genes on one X chromosome in female
mammals, but some genes escape XCI. To identify escape genes in vivo and to explore …

Myelinating oligodendrocytes enable fast propagation of action potentials along the
ensheathed axons. In addition, oligodendrocytes play diverse non-canonical roles including …

Rapid conduction of nerve impulses requires coating of axons by myelin sheaths, which are
lipid-rich and multilamellar membrane stacks. The lipid composition of myelin varies …

Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high
abundance of membrane lipids is one of myelin's salient features that contribute to its unique …

Myelin membranes are dominated by lipids while the complexity of their protein composition
has long been considered to be low. However, numerous additional myelin proteins have …

The largest pool of free cholesterol in mammals resides in myelin membranes. Myelin
facilitates rapid saltatory impulse propagation by electrical insulation of axons. This function …

Extracellular vesicles (EVs) have recently emerged as versatile elements of cell
communication in the nervous system, mediating tissue homeostasis. EVs influence the …

Rationale: Remodeling and loss of distal conducting airways, including preterminal and
terminal bronchioles (pre-TBs/TBs), underlie progressive airflow limitation in chronic …