Pharmacogenomics of CYP2C9: Functional and Clinical Considerations

AK Daly, AE Rettie, DM Fowler, JO Miners - Journal of personalized …, 2017 - mdpi.com
CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most
important contributor from this subfamily to drug metabolism. Polymorphisms resulting in …

Mechanisms of cytochrome P450-catalyzed oxidations

FP Guengerich - ACS catalysis, 2018 - ACS Publications
Enzymes are complex biological catalysts and are critical to life. Most oxidations of
chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize …

Roles of Individual Human Cytochrome P450 Enzymes in Drug Metabolism

FP Guengerich - Pharmacological Reviews, 2024 - pharmrev.aspetjournals.org
Our knowledge of the roles of individual cytochrome P450 (P450) enzymes in drug
metabolism has developed considerably in the past 30 years, and this base has been of …

Massively parallel characterization of CYP2C9 variant enzyme activity and abundance

CJ Amorosi, MA Chiasson, MG McDonald… - The American Journal of …, 2021 - cell.com
CYP2C9 encodes a cytochrome P450 enzyme responsible for metabolizing up to 15% of
small molecule drugs, and CYP2C9 variants can alter the safety and efficacy of these …

Synthesis, spectral properties, chemical descriptors and light harvesting studies of a new bioactive azo imidazole compound

VS Kumar, YS Mary, K Pradhan, D Brahman… - Journal of Molecular …, 2020 - Elsevier
The manuscript presents the synthesis and detailed spectral calculations of a new
azoimidazole compound 1-[2-(2-hydroxy-3-methoxy-5-phenylazobenzaldeneamino) ethyl]-3 …

Metabolites of cannabigerol generated by human cytochrome P450s are bioactive

P Roy, DG Dennis, MD Eschbach, SD Anand, F Xu… - Biochemistry, 2022 - ACS Publications
The phytocannabinoid cannabigerol (CBG) is the central biosynthetic precursor to many
cannabinoids, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Though the …

Machine learning-driven identification of drugs inhibiting cytochrome P450 2C9

E Goldwaser, C Laurent, N Lagarde… - PLoS Computational …, 2022 - journals.plos.org
Cytochrome P450 2C9 (CYP2C9) is a major drug-metabolizing enzyme that represents 20%
of the hepatic CYPs and is responsible for the metabolism of 15% of drugs. A general …

Elucidating the Mechanism of Metabolism of Cannabichromene by Human Cytochrome P450s

P Roy, J Maturano, H Hasdemir, A Lopez… - Journal of Natural …, 2024 - ACS Publications
Cannabichromene (CBC) is a nonpsychoactive phytocannabinoid well-known for its wide-
ranging health advantages. However, there is limited knowledge regarding its human …

Characterization of porcine hepatic and intestinal drug metabolizing CYP450: comparison with human orthologues from a quantitative, activity and selectivity …

W Schelstraete, LD Clerck, E Govaert, J Millecam… - Scientific Reports, 2019 - nature.com
Over the past two decades, the pig has gained attention as a potential model for human drug
metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation …

Insights into molecular mechanisms of drug metabolism dysfunction of human CYP2C9* 30

M Louet, CM Labbe, C Fagnen, CM Aono… - PLoS …, 2018 - journals.plos.org
Cytochrome P450 2C9 (CYP2C9) metabolizes about 15% of clinically administrated drugs.
The allelic variant CYP2C9* 30 (A477T) is associated to diminished response to the …