Nitric oxide (NO) is a very reactive molecule, and its short half-life would make it virtually
invisible until its discovery. NO activates soluble guanylyl cyclase (sGC), increasing 3′, 5 …

The adult brain continues to learn and can recover from injury, but the elements and
operation of the neural circuits responsible for this plasticity are not known. In previous work …

Mechanisms thought of as homeostatic must exist to maintain neuronal activity in the brain
within the dynamic range in which neurons can signal. Several distinct mechanisms have …

The mammalian eye-to-brain pathway includes more than 20 parallel circuits, each
consisting of precise long-range connections between specific sets of retinal ganglion cells …

Age-related visual decline and disease due to neural dysfunction are major sources of
disability that have resisted effective treatment. In light of evidence that visual impairment …

Classic studies of ocular dominance plasticity in early development showed that monocular
deprivation suppresses the neural representation and visual function of the deprived eye …

Visual experience during the critical period modulates visual development such that
deprivation causes visual impairments while stimulation induces enhancements. This study …

The temporal closure of one eye in juvenile and young adult mice induces a shift of the
ocular dominance (OD) of neurons in the binocular visual cortex. However, OD plasticity …

In adult mice with unilateral optic nerve crush injury (ONC), we studied visual response
plasticity in the visual cortex following stimulation with sinusoidal grating. We examined …

Degenerative eye diseases are a leading cause of blindness in adults. While only limited
treatment options for diseases such as age related macular degeneration and retinitis …