Irisin is an exercise-induced myokine expressed as a bioactive peptide in multiple tissues
and organs, and exercise and cold exposure are the major inducers for its secretion. Irisin …

Amyotrophic lateral sclerosis (ALS), the major adult-onset motor neuron disease, has been
viewed almost exclusively as a disease of upper and lower motor neurons, with muscle …

The interrelationship between brain, gut and skeletal muscle plays a key role in energy
homeostasis of the body, and is becoming a hot topic of research. Intestinal microbial …

Skeletal muscle health and function are important determinants of systemic metabolic
homeostasis and organism-wide responses, including disease outcome. While it is well …

Recently, it has been demonstrated that in sarcopenic obesity (SO), physical activity could
improve cognitive functions. Moreover, previous studies suggested that muscle contraction …

Neurodegenerative diseases are global health challenges characterized by the progressive
degeneration of nerve cells, leading to cognitive and motor impairments. The brain–gut …

Fibronectin type III domain–containing protein 5 (FNDC5) and its derived hormone, irisin,
have been associated with metabolic control in humans, with described FNDC5 single …

Cold stress disturbs cellular metabolic and energy homeostasis, which is one of the causes
of stress-induced illnesses. O-GlcNAcylation is a nutrient-sensing pathway involved in a …

Background Irisin, an exercise-induced myokine, has been shown to have beneficial effects
on cognitive and metabolic functions. However, previous studies assessing the levels of …

Background: Cathepsin B (CTSB) and brain derived neurotrophic factor (BDNF) are
increased with aerobic exercise (AE) and skeletal muscle has been identified as a potential …