Development of pharmaceutical nanomedicines: from the bench to the market

AA Halwani - Pharmaceutics, 2022 - mdpi.com
Nanotechnology plays a significant role in the field of medicine and in drug delivery, mainly
due to the major limitations affecting the conventional pharmaceutical agents, and older …

Nanoparticle-based delivery systems for vaccines

R Bezbaruah, VP Chavda, L Nongrang, S Alom… - Vaccines, 2022 - mdpi.com
Vaccination is still the most cost-effective way to combat infectious illnesses. Conventional
vaccinations may have low immunogenicity and, in most situations, only provide partial …

Polymeric nanocapsules as nanotechnological alternative for drug delivery system: current status, challenges and opportunities

S Deng, MR Gigliobianco, R Censi, P Di Martino - Nanomaterials, 2020 - mdpi.com
Polymer-based nanocapsules have been widely studied as a potential drug delivery system
in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique …

Challenges in development of nanoparticle-based therapeutics

N Desai - The AAPS journal, 2012 - Springer
In recent years, nanotechnology has been increasingly applied to the area of drug
development. Nanoparticle-based therapeutics can confer the ability to overcome biological …

The potential anti‐infective applications of metal oxide nanoparticles: A systematic review

Y Abo‐zeid, GR Williams - Wiley Interdisciplinary Reviews …, 2020 - Wiley Online Library
Microbial infections present a major global healthcare challenge, in large part because of
the development of microbial resistance to the currently approved antimicrobial drugs. This …

Endotoxin contamination: a key element in the interpretation of nanosafety studies

Y Li, D Boraschi - Nanomedicine, 2016 - Taylor & Francis
The study of toxicity and potential risks of engineered nanoparticles is of particular
importance in nanomedicine. Endotoxin, a common contaminant of bacterial origin, has …

Sterilization of hydrogels for biomedical applications: A review

R Galante, TJA Pinto, R Colaco… - Journal of Biomedical …, 2018 - Wiley Online Library
Despite the beneficial properties and outstanding potential of hydrogels for biomedical
applications, several unmet challenges must be overcome, especially regarding to their …

Facilitating the translation of nanomedicines to a clinical product: challenges and opportunities

V Agrahari, V Agrahari - Drug Discovery Today, 2018 - Elsevier
Highlights•Clinical translation and commercialization challenges of nanomedicine products.•
Manufacturing or scale-up, characterization, safety, stability and efficacy …

Challenges facing sterilization and depyrogenation of nanoparticles: Effects on structural stability and biomedical applications

MA Vetten, CS Yah, T Singh, M Gulumian - … : Nanotechnology, Biology and …, 2014 - Elsevier
This review outlines and compares techniques that are currently available for the
sterilization of nanoparticles and addresses the topic of endotoxin contamination. Several …

Growth-promoting gold nanoparticles decrease stress responses in Arabidopsis seedlings

E Ferrari, F Barbero, M Busquets-Fité, M Franz-Wachtel… - Nanomaterials, 2021 - mdpi.com
The global economic success of man-made nanoscale materials has led to a higher
production rate and diversification of emission sources in the environment. For these …