Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as
well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the …

Alzheimer's disease (AD) is the most common form of dementia among the elderly,
accounting for 60% to 70% of cases. At present, the pathogenesis of this condition remains …

Flavonoids, a series of compounds with a C6-C3-C6 structure, mostly originate from plant
metabolism. Flavonoids have shown beneficial effects on many aspects of human …

Background: Flavones are one of the main subclasses of flavonoids with diverse
pharmacological properties. They have been reported to possess antimalarial, antimicrobial …

Abstract Histamine H3 receptors (H3R), belonging to G‐protein coupled receptors (GPCR)
class A superfamily, are responsible for modulating the release of histamine as well as of …

A series of novel isoflavone analogs were designed, synthesized, and evaluated as
multitarget-directed ligands for the treatment of Alzheimer's disease. In vitro evaluations …

Rhodopsin (Rho) is a visual G protein–coupled receptor expressed in the rod
photoreceptors of the eye, where it mediates transmission of a light signal into a cell and …

Abstract Alzheimer′ s disease (AD), a neurodegenerative disease responsible for death of
millions of people worldwide is a progressive clinical disorder which causes neurons to …

The recent developments of fast reliable docking, virtual screening and other algorithms
gave rise to discovery of many novel ligands of histamine receptors that could be used for …

The part of the influenza polymerase PA subunit featuring endonuclease activity is a target
for anti-influenza therapies, including the FDA-approved drug Xofluza. A general feature of …