Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Conspectus Metal ions have been identified as key factors modulating the aggregation of
amyloid-β peptide (Aβ) implicated in Alzheimer's disease (AD). The presence of elevated …

Aggregation of amyloid-β (Aβ) by self-assembly into oligomers or amyloids is a central event
in Alzheimer's disease. Coordination of transition-metal ions, mainly copper and zinc, to Aβ …

There are a group of diseases associated with protein misfolding and accumulation into
amyloid fibers. Many of these diseases have a major impact on human health, in particular …

Abstract 2012 has been another year in which multiple large-scale clinical trials for
Alzheimer's disease (AD) have failed to meet their clinical endpoints. With the social and …

Context: Involvement of reactive oxygen species (ROS) in a variety of physiological and
pathological processes has attracted a growing interest. In fact, identification of this global …

Copper is a redox-active metal with many important biological roles. Consequently, its
distribution and oxidation state are subject to stringent regulation. A large body of …

In the present perspective, we give a critical review on the coordination chemistry of the
metal ions copper and zinc to the amyloid-β (Aβ) peptide; such complexes have been linked …

Although a key factor in Alzheimer's disease etiology is enrichment of Zn2+ in aggregates,
and there are data suggesting that zinc promotes aggregation, how Zn2+-A β coordination …

The metal ions copper, zinc and iron have been shown to be involved in Alzheimer's
disease (AD). Cu, Zn and Fe ions are proposed to be implicated in two key steps of AD …