Efficacy and safety of ketamine vs electroconvulsive therapy among patients with major depressive episode: a systematic review and meta-analysis
Importance Whether ketamine is as effective as electroconvulsive therapy (ECT) among
patients with major depressive episode remains unknown. Objective To systematically …
patients with major depressive episode remains unknown. Objective To systematically …
Novel drug developmental strategies for treatment‐resistant depression
Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …
therapies are ineffective in many patients, novel strategies are needed to overcome …
Real-world experience of esketamine use to manage treatment-resistant depression: a multicentric study on safety and effectiveness (REAL-ESK study)
Abstract Background Treatment-resistant Depression (TRD) represents a widespread
disorder with significant direct and indirect healthcare costs. esketamine, the S-enantiomer …
disorder with significant direct and indirect healthcare costs. esketamine, the S-enantiomer …
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter
P Plenge, D Yang, K Salomon, L Laursen… - Nature …, 2021 - nature.com
Depression is a common mental disorder. The standard medical treatment is the selective
serotonin reuptake inhibitors (SSRIs). All characterized SSRIs are competitive inhibitors of …
serotonin reuptake inhibitors (SSRIs). All characterized SSRIs are competitive inhibitors of …
Efficacy and tolerability of combination treatments for major depression: antidepressants plus second-generation antipsychotics vs. esketamine vs. lithium
GH Vázquez, A Bahji, J Undurraga… - Journal of …, 2021 - journals.sagepub.com
Background: Successful treatment of major depressive disorder (MDD) can be challenging,
and failures (" treatment-resistant depression"[TRD]) are frequent. Steps to address TRD …
and failures (" treatment-resistant depression"[TRD]) are frequent. Steps to address TRD …
Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression
Background Selective serotonin reuptaker inhibitors, including fluoxetine, are widely studied
and prescribed antidepressants, while their exact molecular and cellular mechanism are yet …
and prescribed antidepressants, while their exact molecular and cellular mechanism are yet …
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety
There is an urgent need to derive quantitative measures based on coherent neurobiological
dysfunctions or 'biotypes' to enable stratification of patients with depression and anxiety. We …
dysfunctions or 'biotypes' to enable stratification of patients with depression and anxiety. We …
Investigating the role of maintenance TMS protocols for major depression: systematic review and future perspectives for personalized interventions
G d'Andrea, G Mancusi, MC Santovito… - Journal of Personalized …, 2023 - mdpi.com
Repetitive Transcranial Magnetic Stimulation (rTMS) has been approved by the FDA as an
effective intervention for Treatment-Resistant Depression (TRD). However, there is little …
effective intervention for Treatment-Resistant Depression (TRD). However, there is little …
Perspectives for therapy of treatment‐resistant depression
M Papp, WJ Cubała, L Swiecicki… - British Journal of …, 2022 - Wiley Online Library
A high proportion of depressed patients fail to respond to antidepressant drug treatment.
Treatment‐resistant depression (TRD) is a major challenge for the psychopharmacology of …
Treatment‐resistant depression (TRD) is a major challenge for the psychopharmacology of …
A clinical approach to treatment resistance in depressed patients: What to do when the usual treatments don't work well enough?
Background Major depressive disorder is a common, recurrent, disabling and costly disorder
that is often severe and/or chronic, and for which non-remission on guideline concordant first …
that is often severe and/or chronic, and for which non-remission on guideline concordant first …