TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
Vitamin C and immune cell function in inflammation and cancer
Vitamin C (ascorbate) is maintained at high levels in most immune cells and can affect many
aspects of the immune response. Intracellular levels generally respond to variations in …
aspects of the immune response. Intracellular levels generally respond to variations in …
CD4 helper and CD8 cytotoxic T cell differentiation
I Taniuchi - Annual review of Immunology, 2018 - annualreviews.org
A fundamental question in developmental immunology is how bipotential thymocyte
precursors generate both CD4+ helper and CD8+ cytotoxic T cell lineages. The MHC …
precursors generate both CD4+ helper and CD8+ cytotoxic T cell lineages. The MHC …
[HTML][HTML] Navigating the DNA methylation landscape of cancer
A Nishiyama, M Nakanishi - Trends in Genetics, 2021 - cell.com
DNA methylation is a chemical modification that defines cell type and lineage through the
control of gene expression and genome stability. Disruption of DNA methylation control …
control of gene expression and genome stability. Disruption of DNA methylation control …
Non-coding transcription instructs chromatin folding and compartmentalization to dictate enhancer-promoter communication and T cell fate
It is now established that Bcl11b specifies T cell fate. Here, we show that in developing T
cells, the Bcl11b enhancer repositioned from the lamina to the nuclear interior. Our search …
cells, the Bcl11b enhancer repositioned from the lamina to the nuclear interior. Our search …
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
TET deficiency perturbs mature B cell homeostasis and promotes oncogenesis associated with accumulation of G-quadruplex and R-loop structures
Enzymes of the TET family are methylcytosine dioxygenases that undergo frequent
mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations …
mutational or functional inactivation in human cancers. Recurrent loss-of-function mutations …
The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression
JN Kanbar, S Ma, ES Kim, NS Kurd, MS Tsai… - Journal of Experimental …, 2022 - rupress.org
During an immune response to microbial infection, CD8+ T cells give rise to short-lived
effector cells and memory cells that provide sustained protection. Although the …
effector cells and memory cells that provide sustained protection. Although the …
Loss of TET2 and TET3 in regulatory T cells unleashes effector function
TET enzymes oxidize 5-methylcytosine to 5-hydroxymethylcytosine and other oxidized
methylcytosines in DNA. Here we examine the role of TET proteins in regulatory T (Treg) …
methylcytosines in DNA. Here we examine the role of TET proteins in regulatory T (Treg) …
TET enzymes and 5hmC in adaptive and innate immune systems
DNA methylation is an abundant and stable epigenetic modification that allows inheritance
of information from parental to daughter cells. At active genomic regions, DNA methylation …
of information from parental to daughter cells. At active genomic regions, DNA methylation …