Mitochondria are important for providing cellular energy ATP through the oxidative
phosphorylation pathway. They are also critical in regulating many cellular functions …

Previous studies have found that intracorporal short-chain fatty acids (SCFAs), as the main
metabolites of the gut microbiota, play important roles in the intestinal physiology and …

The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of
certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a …

Quercetin, one of the major flavonoids in plants, has been recently reported to have
neuroprotective effects against neurodegenerative processes. However, since the molecular …

Sodium butyrate (NaB) has exhibited protective activity in neurological disorders. Here, we
investigated the neuroprotective effect and potential mechanisms of NaB in a mouse model …

Sustained neuroinflammation mediated by resident microglia is recognized as a key
pathophysiological contributor to many neurodegenerative diseases, including Parkinson's …

The epigenomic landscape of Parkinson's disease (PD) remains unknown. We performed a
genomewide DNA methylation and a transcriptome studies in induced pluripotent stem cell …

The bidirectional interaction between the gut microbiota (GM) and the Central Nervous
System, the so-called gut microbiota brain axis (GMBA), deeply affects brain function and …

Acetylation is a key post-translational modification (PTM) involved in the regulation of both
histone and non-histone proteins. It controls cellular processes such as DNA transcription …

Neurodegenerative diseases are a major burden for our society, affecting millions of people
worldwide. A main goal of past and current research is to enhance our understanding of the …