Circulating miRNA analysis for cancer diagnostics and therapy
Successful treatment of cancer depends on early diagnosis and effective monitoring of
patients' response to therapy. Traditional tools based on tumor biopsies lack the sensitivity …
patients' response to therapy. Traditional tools based on tumor biopsies lack the sensitivity …
Small RNA-sequencing: approaches and considerations for miRNA analysis
S Benesova, M Kubista, L Valihrach - Diagnostics, 2021 - mdpi.com
MicroRNAs (miRNAs) are a class of small RNA molecules that have an important regulatory
role in multiple physiological and pathological processes. Their disease-specific profiles and …
role in multiple physiological and pathological processes. Their disease-specific profiles and …
Multi-omics of 34 colorectal cancer cell lines-a resource for biomedical studies
KCG Berg, PW Eide, IA Eilertsen, B Johannessen… - Molecular cancer, 2017 - Springer
Background Colorectal cancer (CRC) cell lines are widely used pre-clinical model systems.
Comprehensive insights into their molecular characteristics may improve model selection for …
Comprehensive insights into their molecular characteristics may improve model selection for …
Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling
MD Giraldez, RM Spengler, A Etheridge… - Nature …, 2018 - nature.com
RNA-seq is increasingly used for quantitative profiling of small RNAs (for example,
microRNAs, piRNAs and snoRNAs) in diverse sample types, including isolated cells, tissues …
microRNAs, piRNAs and snoRNAs) in diverse sample types, including isolated cells, tissues …
Chromosomal-level assembly of the Asian seabass genome using long sequence reads and multi-layered scaffolding
We report here the~ 670 Mb genome assembly of the Asian seabass (Lates calcarifer), a
tropical marine teleost. We used long-read sequencing augmented by transcriptomics …
tropical marine teleost. We used long-read sequencing augmented by transcriptomics …
Systematic comparison of small RNA library preparation protocols for next-generation sequencing
C Dard-Dascot, D Naquin, Y D'Aubenton-Carafa, K Alix… - BMC genomics, 2018 - Springer
Background Next-generation sequencing technologies have revolutionized the study of
small RNAs (sRNAs) on a genome-wide scale. However, classical sRNA library preparation …
small RNAs (sRNAs) on a genome-wide scale. However, classical sRNA library preparation …
Bias-minimized quantification of microRNA reveals widespread alternative processing and 3′ end modification
MicroRNAs (miRNAs) modulate diverse biological and pathological processes via post-
transcriptional gene silencing. High-throughput small RNA sequencing (sRNA-seq) has …
transcriptional gene silencing. High-throughput small RNA sequencing (sRNA-seq) has …
Evolution of flower color pattern through selection on regulatory small RNAs
Small RNAs (sRNAs) regulate genes in plants and animals. Here, we show that population-
wide differences in color patterns in snapdragon flowers are caused by an inverted …
wide differences in color patterns in snapdragon flowers are caused by an inverted …
Microguards and micromessengers of the genome
The regulation of gene expression is of fundamental importance to maintain organismal
function and integrity and requires a multifaceted and highly ordered sequence of events …
function and integrity and requires a multifaceted and highly ordered sequence of events …
Mechanistic insights into non-coding Y RNA processing
ABSTRACT Y RNAs (84–112 nt) are non-coding RNAs transcribed by RNA polymerase III
and are characterized by a distinctive secondary structure. Human Y RNAs interact with the …
and are characterized by a distinctive secondary structure. Human Y RNAs interact with the …