Mitochondria are essential for tumor growth and progression. However, the heavy demand
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …

Background The early life environment experienced by an individual in utero and during the
neonatal period is a major factor in shaping later life disease risk-including susceptibility to …

A little over 5 years ago, the US National Institutes of Health (NIH) announced the intention
to develop policies to require applicants to report plans to balance male and female cells …

Addressing the increasing popularity of nutraceuticals, dietary supplements, and functional
foods, this comprehensive and timely book presents an abundance of information on herbal …

Estrogen is an essential sex steroid hormone that functions primarily in female reproductive
system, as well as in a variety of tissues and organs with pleiotropic effects, such as in …

Background Obesity and the metabolic syndrome are increasingly prevalent in society and
their complications and response to treatment exhibit sexual dimorphism. Mouse models of …

Type 2 diabetes (T2D) is characterized by insulin resistance along with pancreatic β cell
failure. β cell factors are traditionally thought to control glucose homeostasis by modulating …

Loss of estrogens at menopause is a major cause of osteoporosis and increased fracture
risk. Estrogens protect against bone loss by decreasing osteoclast number through direct …

Obesity is heightened during aging, and although the estrogen receptor α (ERα) has been
implicated in the prevention of obesity, its molecular actions in adipocytes remain …

In contrast to mice, zebrafish have an exceptional yet elusive ability to replenish lost β cells
in adulthood. Understanding this framework would provide mechanistic insights for β cell …