Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …

The epithelial-to-mesenchymal transition (EMT) is frequently co-opted by cancer cells to
enhance migratory and invasive cell traits. It is a key contributor to heterogeneity …

Tumor metastasis is a hallmark of cancer. Metastatic cancer cells often reside in distal
tissues and organs in their dormant state. Mechanisms underlying the pre-metastatic niche …

MicroRNAs (miRNAs) negatively and post-transcriptionally regulate expression of multiple
target genes to support anabolic pathways for bone formation. Here, we show that miR-218 …

Abstract Background Triple Negative subset of (TN) Breast Cancers (BC), a close associate
of the basal-like subtype (with limited discordance) is an aggressive form of the disease …

Runt-related transcription factor 2 (RUNX2) is an osteogenesis-related transcription factor
that has emerged as a prominent transcription repressing factor in carcinogenesis. However …

Breast cancer (BC) as one of the most common causes of human deaths among women, is
always considered one of the global health challenges. Despite various advances in …

The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …

Renal fibrosis is widely considered a common mechanism leading to end-stage renal
failure. Epithelial-to-mesenchymal transition (EMT) plays important roles in the pathogenesis …