Patients with chronic kidney disease (CKD) are at an increased risk of premature mortality,
mainly from cardiovascular causes. The association between CKD on hemodialysis and …

Patients with chronic kidney failure—defined as a glomerular filtration rate persistently below
15 mL/min per 1· 73 m 2—have an unacceptably high mortality rate. In developing countries …

The synthesis of structurally diverse amines is of fundamental significance in the
pharmaceutical industry due to the ubiquitous presence of amine motifs in biologically active …

The extracellular calcium-sensing receptor, CaSR, is a member of the G protein-coupled
receptor superfamily and has a critical role in modulating Ca2+ homeostasis via its role in …

Background Calcimimetic agents lower abnormal serum parathyroid hormone (PTH) levels
in people who have chronic kidney disease (CKD), but the benefits and harms on patient …

Background A significant proportion of patients with chronic kidney disease and secondary
hyperparathyroidism (HPT) remain hyperparathyroid after kidney transplantation, a state …

Rationale & Objective Comparative benefits and harms of calcimimetic agents used for the
treatment of secondary hyperparathyroidism have not been well characterized. We sought to …

Uremic secondary hyperparathyroidism is a multifactorial and complex disease often
present in advanced stages of chronic kidney disease. The accumulation of phosphate, the …

Background Monitoring of serum alkaline phosphatase (ALP) is recommended in the
management of chronic kidney disease-mineral and bone disorder (CKD-MBD). However …

The clinical picture of the uraemic syndrome is a complex amalgam of accelerated ageing
and organ dysfunction, which progress in parallel to chronic kidney disease. The uraemic …