Fuchs endothelial corneal dystrophy: The vicious cycle of Fuchs pathogenesis

SO Tone, V Kocaba, M Böhm, A Wylegala… - Progress in Retinal and …, 2021 - Elsevier
Fuchs endothelial corneal dystrophy (FECD) is the most common primary corneal
endothelial dystrophy and the leading indication for corneal transplantation worldwide …

Fuchs endothelial corneal dystrophy: clinical, genetic, pathophysiologic, and therapeutic aspects

M Matthaei, A Hribek, T Clahsen… - Annual review of …, 2019 - annualreviews.org
Fuchs endothelial corneal dystrophy (FECD) is a bilateral corneal endothelial disorder and
the most common cause of corneal transplantation worldwide. Professor Ernst Fuchs …

Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy

NA Afshari, RP Igo Jr, NJ Morris, D Stambolian… - Nature …, 2017 - nature.com
The structure of the cornea is vital to its transparency, and dystrophies that disrupt corneal
organization are highly heritable. To understand the genetic aetiology of Fuchs endothelial …

Diseases of the corneal endothelium

LJ Jeang, CE Margo, EM Espana - Experimental eye research, 2021 - Elsevier
The corneal endothelial monolayer and associated Descemet's membrane (DM) complex is
a unique structure that plays an essential role in corneal function. Endothelial cells are …

Mitochondrial dysfunction and mitophagy in Fuchs endothelial corneal dystrophy

V Kumar, UV Jurkunas - Cells, 2021 - mdpi.com
Fuchs endothelial corneal dystrophy (FECD) is a genetically complex, heterogenous, age-
related degenerative disease of corneal endothelial cells (CEnCs), occurring in the fifth …

Association of the gutta-induced microenvironment with corneal endothelial cell behavior and demise in Fuchs endothelial corneal dystrophy

V Kocaba, KR Katikireddy, I Gipson… - JAMA …, 2018 - jamanetwork.com
Importance The number and size of guttae increase over time in Fuchs endothelial corneal
dystrophy (FECD); however, the association between these physical parameters and …

Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies

NS Nielsen, ET Poulsen, MV Lukassen… - Progress in Retinal and …, 2020 - Elsevier
Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the
second most abundant protein in the corneal stroma. In this review, we summarize the …

Trinucleotide repeat expansion in the transcription factor 4 (TCF4) gene leads to widespread mRNA splicing changes in Fuchs' endothelial corneal dystrophy

ED Wieben, RA Aleff, X Tang, ML Butz… - … & Visual Science, 2017 - iovs.arvojournals.org
Purpose: To identify RNA missplicing events in human corneal endothelial tissue isolated
from Fuchs' endothelial corneal dystrophy (FECD). Methods: Total RNA was isolated and …

Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain

M Richner, LT Pallesen, M Ulrichsen, ET Poulsen… - Science …, 2019 - science.org
Neuropathic pain is a major incurable clinical problem resulting from peripheral nerve
trauma or disease. A central mechanism is the reduced expression of the potassium chloride …

The ultrastructures and mechanical properties of the descement's membrane in fuchs endothelial corneal dystrophy

D Xia, S Zhang, E Nielsen, AR Ivarsen, C Liang, Q Li… - Scientific reports, 2016 - nature.com
Fuchs endothelial corneal dystrophy (FECD), is the most common corneal endothelial
dystrophy, and contributes up to 50% of all corneal transplantations performed in developed …