Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers
Drug repurposing is promoted as a cost-and time-effective mechanism for providing new
medicines. Often, however, there is insufficient consideration by academic researchers of …
medicines. Often, however, there is insufficient consideration by academic researchers of …
[HTML][HTML] Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics
With more than 5 million fatalities and close to 300 million reported cases, COVID-19 is the
first documented pandemic due to a coronavirus that continues to be a major health …
first documented pandemic due to a coronavirus that continues to be a major health …
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2
S Krasemann, U Haferkamp, S Pfefferle, MS Woo… - Stem cell reports, 2022 - cell.com
Neurological complications are common in COVID-19. Although SARS-CoV-2 has been
detected in patients' brain tissues, its entry routes and resulting consequences are not well …
detected in patients' brain tissues, its entry routes and resulting consequences are not well …
Comparison of IgA, IgG, and neutralizing antibody responses following immunization with Moderna, BioNTech, AstraZeneca, Sputnik-V, Johnson and Johnson, and …
T Adjobimey, J Meyer, L Sollberg, M Bawolt… - Frontiers in …, 2022 - frontiersin.org
In an ongoing multinational trial, we obtained blood samples from 365 volunteers vaccinated
with mRNA vaccines (Moderna, BioNTech), viral DNA-vectored vaccines (AstraZeneca …
with mRNA vaccines (Moderna, BioNTech), viral DNA-vectored vaccines (AstraZeneca …
A machine learning platform to estimate anti-SARS-CoV-2 activities
Strategies for drug discovery and repositioning are urgently need with respect to COVID-19.
Here we present REDIAL-2020, a suite of computational models for estimating small …
Here we present REDIAL-2020, a suite of computational models for estimating small …
Papaverine: a miraculous alkaloid from opium and its multimedicinal application
The pharmacological actions of benzylisoquinoline alkaloids are quite substantial, and have
recently attracted much attention. One of the principle benzylisoquinoline alkaloids has been …
recently attracted much attention. One of the principle benzylisoquinoline alkaloids has been …
Different aspects of emetine's capabilities as a highly potent SARS-CoV-2 inhibitor against COVID-19
M Valipour - ACS Pharmacology & Translational Science, 2022 - ACS Publications
In the global movement to find the appropriate agents to fight the coronavirus disease of
2019 (COVID-19), emetine is one of the strongest anti-SARS-CoV-2 compounds with sub …
2019 (COVID-19), emetine is one of the strongest anti-SARS-CoV-2 compounds with sub …
Dual action anti‐inflammatory/antiviral isoquinoline alkaloids as potent naturally occurring anti‐SARS‐CoV‐2 agents: A combined pharmacological and medicinal …
In the search for compounds that inhibit the SARS‐CoV‐2 after the onset of the COVID‐19
pandemic, isoquinoline‐containing alkaloids have been identified as compounds with high …
pandemic, isoquinoline‐containing alkaloids have been identified as compounds with high …
Learning from COVID-19: How drug hunters can prepare for the next pandemic
Highlights•We provide a brief perspective of our 3 years of COVID-19 research.•We describe
the molecules repurposed with activity against SARS-CoV-2.•The foundational work prior to …
the molecules repurposed with activity against SARS-CoV-2.•The foundational work prior to …
Natural products-based drug design against SARS-CoV-2 Mpro 3CLpro
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has received global attention due to the serious threat it poses …
coronavirus 2 (SARS-CoV-2), has received global attention due to the serious threat it poses …