Cell cycle progression is a tightly regulated process by which DNA replicates and cell
reproduces. The major driving force underlying cell cycle progression is the sequential …

Mammalian cells encode three D cyclins (D1, D2, and D3) that coordinately function as
allosteric regulators of cyclin-dependent kinase 4 (CDK4) and CDK6 to regulate cell cycle …

Eukaryotic cell biology depends on cullin–RING E3 ligase (CRL)-catalysed protein
ubiquitylation, which is tightly controlled by the modification of cullin with the ubiquitin-like …

Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified
more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased …

E3 ligases are typically classified by hallmark domains such as RING and RBR, which are
thought to specify unique catalytic mechanisms of ubiquitin transfer to recruited substrates …

S phase kinase-associated protein 1 (SKP1)–cullin 1 (CUL1)–F-box protein (SCF) ubiquitin
ligase complexes use a family of F-box proteins as substrate adaptors to mediate the …

Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory
mechanisms and pathological implications remain poorly understood. Here, via a …

The WD40 domain exhibits a β-propeller architecture, often comprising seven blades. The
WD40 domain is one of the most abundant domains and also among the top interacting …

Plants, like other eukaryotes, rely on proteolysis to control the abundance of key regulatory
proteins and enzymes. Strikingly, genome-wide studies have revealed that the ubiquitin-26S …

Cullin–RING complexes comprise the largest known class of ubiquitin ligases. Owing to the
great diversity of their substrate-receptor subunits, it is possible that there are hundreds of …