[HTML][HTML] Application of pseudovirus system in the development of vaccine, antiviral-drugs, and neutralizing antibodies

Q Xiang, L Li, J Wu, M Tian, Y Fu - Microbiological Research, 2022 - Elsevier
Pseudoviruses are viral particles coated with a heterologous envelope protein, which
mediates the entry of pseudoviruses as efficiently as that of the live viruses possessing high …

Sub‐lineages of the SARS‐CoV‐2 Omicron variants: Characteristics and prevention

A Xu, B Hong, F Lou, S Wang, W Li, A Shafqat… - MedComm, 2022 - Wiley Online Library
Since the start of the coronavirus disease 2019 (COVID‐19) pandemic, new variants of
severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) have emerged …

Developing pseudovirus-based neutralization assay against omicron-included SARS-CoV-2 variants

H Sun, J Xu, G Zhang, J Han, M Hao, Z Chen, T Fang… - Viruses, 2022 - mdpi.com
The global spread of SARS-CoV-2 and its variants poses a serious threat to human health
worldwide. Recently, the emergence of Omicron has presented a new challenge to the …

Development of a screening platform to discover natural products active against SARS-CoV-2 infection using lung organoid models

JE Lee, SY Jeong, Z Li, HY Kim, HW Kim, MJ Yoo… - Biomaterials …, 2023 - Springer
Background Natural products can serve as one of the alternatives, exhibiting high potential
for the treatment and prevention of COVID-19, caused by SARS-CoV-2. Herein, we report a …

An efficient plasmid-based system for the recovery of recombinant vesicular stomatitis virus encoding foreign glycoproteins

MC Marqués, I Andreu-Moreno, R Sanjuán… - Scientific Reports, 2024 - nature.com
Viral glycoproteins mediate entry into host cells, thereby dictating host range and
pathogenesis. In addition, they constitute the principal target of neutralizing antibody …

Targeting Viral and Cellular Cysteine Proteases for Treatment of New Variants of SARS-CoV-2

D Gentile, L Chiummiento, A Santarsiere, M Funicello… - Viruses, 2024 - mdpi.com
The continuous emergence of SARS-CoV-2 variants caused the persistence of the COVID-
19 epidemic and challenged the effectiveness of the existing vaccines. The viral proteases …

Characterization of a vesicular stomatitis virus-vectored recombinant virus bearing spike protein of SARS-CoV-2 Delta variant

W He, H Cui, S Wang, B Liang, C Zhang, W Wang… - Microorganisms, 2023 - mdpi.com
The frequent emergence of SARS-CoV-2 variants thwarts the prophylactic and therapeutic
countermeasures confronting COVID-19. Among them, the Delta variant attracts widespread …

Strictinin, a major ingredient in Yunnan kucha tea possessing inhibitory activity on the infection of mouse hepatitis virus to mouse L cells

EC Tu, WL Hsu, JTC Tzen - Molecules, 2023 - mdpi.com
Theacrine and strictinin of Yunnan Kucha tea prepared from a mutant variety of wild Pu'er
tea plants were two major ingredients responsible for the anti-influenza activity. As the …

A new intracellular targeting motif in the cytoplasmic tail of the spike protein may act as a target to inhibit SARS-CoV-2 assembly

L Hu, Y Tang, L Mei, M Liang, J Huang, X Wang, L Wu… - Antiviral Research, 2023 - Elsevier
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a
threat to global public health, underscoring the urgent need for the development of …

Variant-specific interactions at the plasma membrane: Heparan sulfate's impact on SARS-CoV-2 binding kinetics

DV Conca, F Bano, J Wirén, L Scherrer, J Svirelis… - bioRxiv, 2024 - biorxiv.org
The worldwide spread of SARS-CoV-2 has been characterised by the emergence of several
variants of concern (VOCs) presenting an increasing number of mutations in the viral …