Schizophrenia: a neurodevelopmental disorder—integrative genomic hypothesis and therapeutic implications from a transgenic mouse model

MK Stachowiak, A Kucinski, R Curl, C Syposs… - Schizophrenia …, 2013 - Elsevier
Schizophrenia is a neurodevelopmental disorder featuring complex aberrations in the
structure, wiring, and chemistry of multiple neuronal systems. The abnormal developmental …

Evidence‐based theory for integrated genome regulation of ontogeny—An unprecedented role of nuclear FGFR1 signaling

MK Stachowiak, EK Stachowiak - Journal of cellular physiology, 2016 - Wiley Online Library
Genetic experiments have positioned the fgfr1 gene at the top of the gene hierarchy that
governs gastrulation, as well as the subsequent development of the major body axes …

Common developmental genome deprogramming in schizophrenia—Role of Integrative Nuclear FGFR1 Signaling (INFS)

ST Narla, YW Lee, CA Benson, P Sarder… - Schizophrenia …, 2017 - Elsevier
The watershed-hypothesis of schizophrenia asserts that over 200 different mutations
dysregulate distinct pathways that converge on an unspecified common mechanism (s) that …

Global developmental gene programing involves a nuclear form of fibroblast growth factor receptor-1 (FGFR1)

C Terranova, ST Narla, YW Lee, J Bard, A Parikh… - PloS one, 2015 - journals.plos.org
Genetic studies have placed the Fgfr1 gene at the top of major ontogenic pathways that
enable gastrulation, tissue development and organogenesis. Using genome-wide …

Nuclear FGF receptor‐1 and CREB binding protein: an integrative signaling module

MK Stachowiak, B Birkaya, JM Aletta… - Journal of cellular …, 2015 - Wiley Online Library
In this review we summarize the current understanding of a novel integrative function of
Fibroblast Growth Factor Receptor‐1 (FGFR1) and its partner CREB Binding Protein (CBP) …

Cooperation of nuclear fibroblast growth factor receptor 1 and Nurr1 offers new interactive mechanism in postmitotic development of mesencephalic dopaminergic …

O Baron, B Förthmann, YW Lee, C Terranova… - Journal of Biological …, 2012 - ASBMB
Experiments in mice deficient for Nurr1 or expressing the dominant-negative FGF receptor
(FGFR) identified orphan nuclear receptor Nurr1 and FGFR1 as essential factors in …

Optogenomic interfaces: Bridging biological networks with the electronic digital world

JM Jornet, Y Bae, CR Handelmann… - Proceedings of the …, 2019 - ieeexplore.ieee.org
The development of optical nano-bio interfaces is a fundamental step toward connecting
biological networks and traditional electronic computing systems. Compared to conventional …

Fibroblast growth factor 2 regulates dopaminergic neuron development in vivo

A Ratzka, O Baron, MK Stachowiak… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 122, 94–105. Abstract Fibroblast growth factor 2 (FGF‐2) is a
neurotrophic factor participating in regulation of proliferation, differentiation, apoptosis and …

NGF-induced cell differentiation and gene activation is mediated by integrative nuclear FGFR1 signaling (INFS)

YW Lee, EK Stachowiak, B Birkaya, C Terranova… - PloS one, 2013 - journals.plos.org
Nerve growth factor (NGF) is the founding member of the polypeptide neurotrophin family
responsible for neuronal differentiation. To determine whether the effects of NGF rely upon …

Alpha7 neuronal nicotinic receptor: a pluripotent target for diseases of the central nervous system

M Bencherif, ST Narla… - CNS & Neurological …, 2014 - ingentaconnect.com
Twenty years ago the alpha7 nicotinic acetylcholine receptor (nAChR) was thought to be
vestigial with little biological relevance, but in recent years it has emerged as a functional …