Dengue virus: pathogenesis and potential for small molecule inhibitors
N Chauhan, KK Gaur, TR Asuru… - Bioscience reports, 2024 - portlandpress.com
Dengue, caused by dengue virus (DENV), is now endemic in nearly 100 countries and
infection incidence is reported in another 30 countries. Yearly an estimated 400 million …
infection incidence is reported in another 30 countries. Yearly an estimated 400 million …
Advances in drug discovery of flavivirus NS2B-NS3pro serine protease inhibitors for the treatment of Dengue, Zika, and West Nile viruses
EE João, JR Lopes, BFR Guedes… - Bioorganic …, 2024 - Elsevier
Flaviviruses are vector-borne RNA viruses that seriously threaten global public health due to
their high transmission index in humans, mainly in endemic areas. They spread infectious …
their high transmission index in humans, mainly in endemic areas. They spread infectious …
Machine learning and molecular docking prediction of potential inhibitors against dengue virus
G Hanson, J Adams, DIB Kepgang, LS Zondagh… - Frontiers in …, 2024 - frontiersin.org
Introduction Dengue Fever continues to pose a global threat due to the widespread
distribution of its vector mosquitoes, Aedes aegypti and Aedes albopictus. While the WHO …
distribution of its vector mosquitoes, Aedes aegypti and Aedes albopictus. While the WHO …
Synthesis and biological activity of imidazole phenazine derivatives as potential inhibitors for NS2B-NS3 dengue protease
A series of new imidazole-phenazine derivatives were synthesized via a two-step process.
The condensation of 2, 3-diaminophenazine and benzaldehyde derivatives proceeds with …
The condensation of 2, 3-diaminophenazine and benzaldehyde derivatives proceeds with …
Identification of novel and potential inhibitors against the dengue virus NS2B/NS3 protease using virtual screening and biomolecular simulations
Approximately 3.9 billion individuals are vulnerable to dengue infection, a prevalent cause
of tropical diseases worldwide. Currently, no drugs are available for preventing or treating …
of tropical diseases worldwide. Currently, no drugs are available for preventing or treating …
Exploring the antiviral inhibitory activity of Niloticin against the NS2B/NS3 protease of Dengue virus (DENV2)
Dengue virus (DENV2) is the cause of dengue disease and a worldwide health problem.
DENV2 replicates in the host cell using polyproteins such as NS3 protease in conjugation …
DENV2 replicates in the host cell using polyproteins such as NS3 protease in conjugation …
The Antiviral Activity of Varenicline against Dengue Virus Replication during the Post-Entry Stage
CL Lin, YT Kiu, JY Kan, YJ Chang, PY Hung, CH Lu… - Biomedicines, 2023 - mdpi.com
Dengue virus (DENV) poses a significant global health challenge, with millions of cases
each year. Developing effective antiviral drugs against DENV remains a major hurdle …
each year. Developing effective antiviral drugs against DENV remains a major hurdle …
[HTML][HTML] Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic Flaviviridae
Dengue, West Nile, Zika, Yellow fever, and Japanese encephalitis viruses persist as
significant global health threats. The development of new therapeutic strategies based on …
significant global health threats. The development of new therapeutic strategies based on …
[HTML][HTML] Discovery of Potent Dengue Virus NS2B-NS3 Protease Inhibitors Among Glycyrrhizic Acid Conjugates with Amino Acids and Dipeptides Esters
YF Lin, HC Lai, CS Lin, PY Hung, JY Kan, SW Chiu… - Viruses, 2024 - mdpi.com
This study investigated a library of known and novel glycyrrhizic acid (GL) conjugates with
amino acids and dipeptide esters, as inhibitors of the DENV NS2B-NS3 protease. We …
amino acids and dipeptide esters, as inhibitors of the DENV NS2B-NS3 protease. We …
Inhibition of dengue viruses by N-methylcytisine thio derivatives through targeting viral envelope protein and NS2B-NS3 protease
CS Lin, CH Lu, TH Lin, YT Kiu, JY Kan… - Bioorganic & Medicinal …, 2024 - Elsevier
Dengue virus (DENV) is a significant global health threat, causing millions of cases
worldwide each year. Developing antiviral drugs for DENV has been a challenging …
worldwide each year. Developing antiviral drugs for DENV has been a challenging …