[HTML][HTML] Exploring HIV-1 Maturation: A New Frontier in Antiviral Development
A McGraw, G Hillmer, SM Medehincu, Y Hikichi… - Viruses, 2024 - mdpi.com
HIV-1 virion maturation is an essential step in the viral replication cycle to produce infectious
virus particles. Gag and Gag-Pol polyproteins are assembled at the plasma membrane of …
virus particles. Gag and Gag-Pol polyproteins are assembled at the plasma membrane of …
30 years of HIV therapy: Current and Future Antiviral Drug Targets
J Nuwagaba, JA Li, B Ngo, RE Sutton - Virology, 2024 - Elsevier
Significant advances in treatment have turned HIV-1 into a manageable chronic condition.
This has been achieved due to highly active antiretroviral therapy (HAART), involving a …
This has been achieved due to highly active antiretroviral therapy (HAART), involving a …
[HTML][HTML] Forty Years of Waiting for Prevention and Cure of HIV Infection–Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug …
DV Parums - … Science Monitor: International Medical Journal of …, 2024 - ncbi.nlm.nih.gov
Abstract In April 1984, 40 years ago, the Secretary of the US Department of Health and
Human Services announced that Dr. Robert Gallo and his colleagues at the National Cancer …
Human Services announced that Dr. Robert Gallo and his colleagues at the National Cancer …
Integrase-LEDGF/p75 complex triggers the formation of biomolecular condensates that modulate HIV-1 integration efficiency in vitro
C Batisse, D Lapaillerie, N Humbert, E Real… - Journal of Biological …, 2024 - ASBMB
The pre-integration steps of the HIV-1 viral cycle are some of the most valuable targets of
recent therapeutic innovations. HIV-1 integrase (IN) displays multiple functions, thanks to its …
recent therapeutic innovations. HIV-1 integrase (IN) displays multiple functions, thanks to its …
Quinolinonyl Derivatives as Dual Inhibitors of the HIV-1 Integrase Catalytic Site and Integrase–RNA interactions
E Patacchini, VN Madia, A Albano… - ACS Medicinal …, 2024 - ACS Publications
The HIV-1 integrase (IN) plays a critical role in the viral lifecycle by integrating the viral DNA
into the host chromosome. The catalytic function of IN has been exploited as a target, with …
into the host chromosome. The catalytic function of IN has been exploited as a target, with …
[HTML][HTML] The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir
Abstract Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are investigational antiretroviral
agents which potently impair virion maturation by inducing hyper-multimerization of IN and …
agents which potently impair virion maturation by inducing hyper-multimerization of IN and …
Disruption of LEDGF/p75-directed integration derepresses antisense transcription of the HIV-1 genome
PR Tedbury, D Mahboubi, M Puray-Chavez, R Shah… - bioRxiv, 2024 - biorxiv.org
Disruption of HIV-1 Integrase (IN) interactions with the host-factor Lens Epithelium-Derived
Growth Factor (LEDGF)/p75 leads to decreased, random integration, increased latent …
Growth Factor (LEDGF)/p75 leads to decreased, random integration, increased latent …