The immune system plays a critical role in our health. No other component of human
physiology plays a decisive role in as diverse an array of maladies, from deadly diseases …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and
common cause of non-traumatic neurological disability in young adults. The likelihood for an …

Multiple sclerosis (MS) is a common autoimmune disease that targets myelin in the central
nervous system (CNS). Multiple genome-wide association studies (GWAS) over the past 10 …

The genetic factors associated with susceptibility or resistance to viral infections are likely to
involve a sophisticated array of immune response. These genetic elements may modulate …

Immunotherapy is rapidly maturing towards extensive clinical use. However, it does not work
well in large patient populations because of an immunosuppressed microenvironment and …

Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II
molecules is crucial for rational development of immunotherapies and vaccines targeting …

Human leukocyte antigen (HLA) genes confer substantial risk for autoimmune diseases on a
log-additive scale. Here we speculated that differences in autoantigen-binding repertoires …

Millions of children are exposed to concentrations of air pollutants, including fine particulate
matter (PM2. 5), above safety standards. In the Mexico City Metropolitan Area (MCMA) …

One of the most common human autoimmune diseases, alopecia areata (AA), is
characterized by sudden, often persisting and psychologically devastating hair loss. Animal …

The human leukocyte antigen (HLA) locus is associated with more complex diseases than
any other locus in the human genome. In many diseases, HLA explains more heritability …