The therapeutic potential of sphingolipids for cardiovascular diseases
S Ya'ar Bar, N Pintel, H Abd Alghne… - Frontiers in …, 2023 - frontiersin.org
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide
and Inflammation plays a critical role in the development of CVD. Despite considerable …
and Inflammation plays a critical role in the development of CVD. Despite considerable …
Potential Drug Targets for Ceramide Metabolism in Cardiovascular Disease
J Guo, J Feng, H Qu, H Xu, H Zhou - Journal of Cardiovascular …, 2022 - mdpi.com
Cardiovascular disease poses a significant threat to the quality of human life. Metabolic
abnormalities caused by excessive caloric intake have been shown to lead to the …
abnormalities caused by excessive caloric intake have been shown to lead to the …
[HTML][HTML] Targeted sphingolipidomics indicates increased C22-C24: 16 ratios of virtually all assayed classes in liver, kidney, and plasma of fumonisin-fed chickens
The biological properties of sphinganine-(d18: 0)-, sphingosine-(d18: 1)-, deoxysphinganine-
(m18: 0)-, deoxysphingosine-(m18: 1)-, deoxymethylsphinganine-(m17: 0) …
(m18: 0)-, deoxysphingosine-(m18: 1)-, deoxymethylsphinganine-(m17: 0) …
[HTML][HTML] Targeted sphingolipid analysis in chickens suggests different mechanisms of fumonisin toxicity in kidney, lung, and brain
Most of the toxic effects of fumonisins can be related to sphingolipid alteration, but there is
little sphingolipidomic data in animals fed fumonisins in organs other than the liver. This …
little sphingolipidomic data in animals fed fumonisins in organs other than the liver. This …
Aryl hydrocarbon receptor inhibition restores indoxyl sulfate-mediated endothelial dysfunction in rat aortic rings
C Nguyen, AJ Edgley, DJ Kelly, AR Kompa - Toxins, 2022 - mdpi.com
The uremic toxin indoxyl sulfate (IS), elevated in chronic kidney disease (CKD), is known to
contribute towards progressive cardiovascular disease. IS activates the aryl hydrocarbon …
contribute towards progressive cardiovascular disease. IS activates the aryl hydrocarbon …
Targeted analysis of sphingolipids in turkeys fed Fusariotoxins: first evidence of key changes that could help explain their relative resistance to Fumonisin toxicity
P Guerre, A Travel, D Tardieu - International Journal of Molecular …, 2022 - mdpi.com
The effects of fumonisins on sphingolipids in turkeys are unknown, except for the increased
sphinganine to sphingosine ratio (Sa: So) used as a biomarker. Fumonisins fed at 20.2 …
sphinganine to sphingosine ratio (Sa: So) used as a biomarker. Fumonisins fed at 20.2 …
[HTML][HTML] Fumonisin Distorts the Cellular Membrane Lipid Profile: A Mechanistic Insight
ALI Omeralfaroug, A Szabó - Toxicology, 2024 - Elsevier
Monitoring modifications in membrane lipids in association with external stimuli/agents,
including fumonisins (FUMs), is a widely employed approach to assess cellular metabolic …
including fumonisins (FUMs), is a widely employed approach to assess cellular metabolic …
Plasma phospholipids profiling changes were associated with the therapeutic response to Roxadustat in peritoneal dialysis patients
YH Yang, Y Saimaiti, Y Zhao, W Tang - Frontiers in Physiology, 2023 - frontiersin.org
Background: Elevated Phospholipids (PLs) and sphingolipid (SM) metabolism relates to with
poor clinical status and adverse outcome of end-stage kidney disease patients undergoing …
poor clinical status and adverse outcome of end-stage kidney disease patients undergoing …