The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,
but new platinum agents have been very slow to enter the clinic. Recently, however, there …

The accidental discovery of the anticancer properties of cisplatin and its clinical introduction
in the 1970s represent a major landmark in the history of successful anticancer drugs …

Metallodrugs offer potential for unique mechanisms of drug action based on the choice of
the metal, its oxidation state, the types and number of coordinated ligands and the …

Since its approval in 1979 cisplatin has become an important component in chemotherapy
regimes for the treatment of ovarian, testicular, lung and bladder cancers, as well as …

Over twenty years of intensive work toward improvement of cisplatin, and with hundreds of
platinum drugs tested, has resulted in the introduction of the widely used carboplatin and of …

Research in the field of bioinorganic chemistry has been stimulated by the worldwide
success of the anticancer drug cisplatin. 40 years after the first report about its biological …

Since the discovery by Rosenberg and collaborators of the antitumor activity of cisplatin 35
years ago, three platinum antitumor drugs (cisplatin, carboplatin and oxaliplatin) have …

Abstract Cisplatin [cis-DDP, cis-diamminedichloroplatinum (II)] is a potent anticancer drug
that has been used successfully to treat tumors of the head, neck, lungs, and genitourinary …

From the metal ions and metal compounds that are known to bind to DNA, many anticancer
Pt (II) and Ru (II)/Ru (III) compounds are known to have ligand-exchange kinetics in the …

The importance of platinum drugs in cancer chemotherapy is underscored by the clinical
success of cisplatin [cis-diamminedichloroplatinum (II)] and its analogues and by clinical …