Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS,
which can be compared across CNS regions, patients, and centres. In patients with multiple …

Background A recent meeting of international imaging experts sponsored by the
International Spinal Research Trust (ISRT) and the Wings for Life Foundation identified 5 …

Diffusion tensor imaging has been used extensively as a research tool to understand the
structural changes associated with white matter pathology. Using water diffusion as the …

Multiple sclerosis (MS) is an inflammatory disorder of the CNS that affects both the brain and
the spinal cord. MRI studies in MS focus more often on the brain than on the spinal cord …

Relapses (episodic exacerbations of neurological signs or symptoms) are a defining feature
of relapsing-remitting multiple sclerosis (MS), the most prevalent MS phenotype. While their …

Diffusion tensor imaging (DTI) is an effective means of quantifying parameters of
demyelination and axonal loss. The application of DTI in Multiple Sclerosis (MS) has yielded …

The spinal cord is a clinically important site that is affected by pathological changes in most
patients with multiple sclerosis; however, imaging of the spinal cord with conventional MRI …

Since its introduction in the early 1990s, diffusion-weighted magnetic resonance imaging
(MRI) has played a crucial role in the non-invasive evaluation of tissue microstructure of …

Background Recent quantitative neuroimaging studies have been successful in capturing
phenotype and genotype-specific changes in dementia syndromes, amyotrophic lateral …

Segmenting the spinal cord contour is a necessary step for quantifying spinal cord atrophy in
various diseases. Delineating gray matter (GM) and white matter (WM) is also useful for …