P4-ATPases comprise a family of P-type ATPases that actively transport or flip phospholipids
across cell membranes. This generates and maintains membrane lipid asymmetry, a …

It is well known that lipids are heterogeneously distributed throughout the cell. Most lipid
species are synthesized in the endoplasmic reticulum (ER) and then distributed to different …

In eukaryotic membranes, type IV P-type adenosine triphosphatases (P4-ATPases) mediate
the translocation of phospholipids from the outer to the inner leaflet and maintain lipid …

This article provides a perspective on major innovations over the past century in research on
the spinal cord and, specifically, on specialized spinal circuits involved in the control of …

Formations of myofibers, osteoclasts, syncytiotrophoblasts, and fertilized zygotes share a
common step, cell–cell fusion. Recent years have brought about considerable progress in …

The negatively charged aminophospholipid, phosphatidylserine (PtdSer), is located in the
inner leaflet of the plasma membrane in normal cells, and may be exposed to the outer …

Phosphatidylserine (PS) is a negatively charged glycerophospholipid found mainly in the
plasma membrane (PM) and in the late secretory/endocytic compartments, where it …

There is currently no accepted classification of autosomal recessive cerebellar ataxias, a
group of disorders characterized by important genetic heterogeneity and complex …

Many neurological conditions are caused by immensely heterogeneous gene mutations.
The diagnostic process is often long and complex with most patients undergoing multiple …

Transport of phospholipids across cell membranes plays a key role in a wide variety of
biological processes. These include membrane biosynthesis, generation and maintenance …