Highlights•Hebbian protocols induce bidirectional plasticity (LTP and LTD) in the
striatum.•Multiple pathways interact to induce activity-dependent STDP in the …

This article aims to provide a synthesis on the question how brain structures cooperate to
accomplish hierarchically organized behaviors, characterized by low‐level, habitual routines …

A remarkable feature of motor control is the ability to coordinate movements across distinct
body parts into a consistent, skilled action. To reach and grasp an object,'gross' arm and …

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is highly effective in
alleviating movement disability in patients with Parkinson's disease (PD). However, its …

Highly synchronous neuronal assembly activity is deemed essential for cognitive brain
function. In theory, such synchrony could coordinate multiple brain areas performing …

The strength of cortical connectivity to the striatum influences the balance between
behavioral variability and stability. Learning to consistently produce a skilled action requires …

Today, the basal ganglia (BG) network can be viewed as a three-layer neural network in
which the striatum and the subthalamic nucleus (STN) are the two BG input structures and …

A popular hypothesis is that the dorsal striatum generates discrete" traffic light" signals that
initiate, maintain, and terminate the execution of learned actions. Alternatively, the striatum …

The activity of neuron populations gives rise to field potentials (FPs) that extend beyond the
sources. Their mixing in the volume dilutes the original temporal motifs in a site-dependent …

Previous studies indicate that the dorsolateral striatum (DLS) integrates sensorimotor
information from cortical and thalamic regions to learn and execute motor habits. However …