Discovery of a relict chloroplast (the apicoplast) in malarial parasites presented new
opportunities for drug development. The apicoplast–although no longer photosynthetic–is …

Fatty acids are primary metabolites synthesized by complex, elegant, and essential
biosynthetic machinery. Fatty acid synthases resemble an iterative assembly line, with an …

The type II fatty acid synthase consists of a series of individual enzymes, each encoded by a
separate gene, that catalyze discrete steps in chain elongation. The formation of fatty acids …

New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …

Resistance to antimicrobial drugs is currently a serious threat to human health.
Consequently, we are facing an urgent need for new antimicrobial drugs acting with original …

Lipid metabolism is of crucial importance for pathogens. Lipids serve as cellular building
blocks, signalling molecules, energy stores, posttranslational modifiers, and pathogenesis …

Understanding ligand− protein recognition and interaction processes is of primary
importance for structure-based drug design. Traditionally, several approaches combining …

Intracellular parasites of the phylum Apicomplexa harbor a plastid-like organelle called
apicoplast that is the most reduced organelle of this type known. Due to the medical …

Abstract Background The Hotdog fold was initially identified in the structure of Escherichia
coli FabA and subsequently in 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp …

Polyketides are among the major classes of bioactive natural products used to treat
microbial infections, cancer, and other diseases. Here we describe a pathway to …